Results 21 to 30 of about 25,432,439 (260)

Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation [PDF]

Molecules, 2017
Tyrosinase is the rate-limiting enzyme critical for melanin synthesis. It controls pigmentation in the skin. Activation of tyrosinase is currently the most common approach in the development of tanning and haircare products. Pratol is a 7-hydroxy-4-methoxyflavone found in Trifolium pratense.
Chung, You Chul, Kim, Seoyeon, Kim, Jin Hwa, Lee, Geun Soo, Lee, Jung No, Lee, Nam Ho, Hyun, Chang-Gu   +6 more
openaire   +3 more sources

MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways [PDF]

, 2010
MafB is a basic leucine zipper transcription factor that plays important roles in development and differentiation processes. During osteoclastogenesis, its expression is downregulated at the transcriptional level via the JNK and p38 MAP kinase pathways ...
Ito, Takashi, Yoshioka, Katsuji, Tanahashi, Hiroshi, Kito, Keiji   +3 more
core   +1 more source

Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2021
Chu-Yun Liu,1 Jian-Hua Wu,1 Zhi-Yuan Chen,1 Yi Zhang,1 Chun-Ling Huang,2 Ai-Mei Lin,1 Xiao-Ting Xu,1 Xiao-Hua Gao1 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China ...
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH   +7 more
doaj  

JNK signaling is the shared pathway linking neuroinflammation, blood–brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain

Journal of Neuroinflammation, 2012
Background White matter injury is the major form of brain damage in very preterm infants. Selective white matter injury in the immature brain can be induced by lipopolysaccharide (LPS)-sensitized hypoxic-ischemia (HI) in the postpartum (P) day 2 rat pups
Wang Lan-Wan, Tu Yi-Fang, Huang Chao-Ching, Ho Chien-Jung   +3 more
doaj   +1 more source

RETRACTED ARTICLE: microRNA-128 mediates CB1 expression and regulates NF-KB/p-JNK axis to influence the occurrence of diabetic bladder disease [PDF]

Journal of Translational Medicine, 2020
Abstract Background Diabetic bladder disease is common complications of diabetes, its symptoms are diverse, can be due to different stages. In this study we investigate the mechanism of miR-128 targeting CB1 expression to mediate the occurrence of ...
Xin Gou, Jing Wu, Mingqing Huang, Yuting Weng, Tongxin Yang, Tao Chen, Guiqing Li, Kewei Fang   +7 more
openaire   +3 more sources

Graphical illustration of the IRE1-JNK-Beclin 1 signaling pathway involved in SADS-CoV-induced autophagy via PLP2-TM and GRP78 interaction.

, 2023
Graphical illustration of the IRE1-JNK-Beclin 1 signaling pathway involved in SADS-CoV-induced autophagy via PLP2-TM and GRP78 interaction.
Jianfei Chen (3186999), Zhaoyang Jing (9110860), Haojie He (14761730), Hongyan Shi (1988656), Dakai Liu (10474934), Da Shi (1455439), Jingyun Ma (1885213), Tingshuai Feng (14761721), Li Feng (77923), Ling Zhou (51948), Jiyu Zhang (725001), Xin Zhang (35492), Mei Xue (163742), Jianbo Liu (315277), Jialin Zhang (320005), Zhaoyang Ji (14761727), Longjun Guo (315268), Liaoyuan Zhang (12157704), Miaomiao Zeng (14761724), Yang Wu (66682)   +19 more
core   +1 more source

The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation [Retraction]

International Journal of COPD, 2023
Chen Z, Zhang Y, Wu J, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:877–885. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Chen Z, Zhang Y, Wu J, Gao X, Huang C, Lin Y, Xu X, Li Y   +7 more
doaj  

Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse

Molecular Pain, 2012
Background Current tools for analgesia are often only partially successful, thus investigations of new targets for pain therapy stimulate great interest. Consequent to peripheral nerve injury, c-Jun N-terminal kinase (JNK) activity in cells of the dorsal
Manassero Giusi, Repetto Ivan E, Cobianchi Stefano, Valsecchi Valeria, Bonny Christophe, Rossi Ferdinando, Vercelli Alessandro   +6 more
doaj   +1 more source

c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells

Journal of Translational Medicine, 2011
Background Autophagy is a dynamic catabolic process characterized by the formation of double membrane vacuoles termed autophagosomes. LC3, a homologue of yeast Atg8, takes part in autophagosome formation, but the exact regulation mechanism of LC3 still ...
Guan Zhong, Ma JianGuo, Xia LiangPing, Wang LinLin, Li DanDan, Sun Ting, Feng GongKan, Zhu XiaoFeng   +7 more
doaj   +1 more source

Propofol Suppressed Hypoxia/Reoxygenation‐Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl‐2, Bax, Caspase3, Kir6.1, and p‐JNK [PDF]

Oxidative Medicine and Cellular Longevity, 2016
Recent studies have found that propofol may protect brain from cerebral ischemic‐reperfusion injury. However, the underlying mechanism remains unclear. The effects of propofol were evaluated in HBVSMC after hypoxia/reoxygenation (H/R). Cell viability and levels of SOD, LDH, and MDA were measured. Apoptosis was detected by flow cytometry.
Zhang, Jianhai, Xia, Yunfei, Xu, Zifeng, Deng, Xiaoming   +3 more
openaire   +2 more sources