Results 31 to 40 of about 25,432,439 (260)
S100A6 Promotes Inflammation and Infiltration of Mononuclear/Macrophages via the p-P38 and p-JNK Pathways in Acute Liver Injury [PDF]
, 2021 Abstract BackgroundThe phagocytic S100 protein, which mediates inflammatory responses and recruits inflammatory cells to sites of tissue damage, has long been known to be expressed in cells of myeloid origin. S100A6 belongs to the A group of the S100 protein family of Ca2+-binding proteins.
He Tong +6 more
openaire +1 more source
BMC Neuroscience, 2013 Background The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and kinases.
Zhu JianXi +7 more
doaj +1 more source
European Journal of Medical Research, 2021 Background The purpose of present study was to explore the mechanism of nuclear factor-kappa B (NF-κB), phosphatidylinositol 3-kinase (PI3K)/protein kinase B(PKB/Akt) and mitogen-activated protein kinase (MAPK) signaling pathways after intervention of ...
Zheng Li +5 more
doaj +1 more source
Propofol reduces anoxia-reoxygenation-induced injury of cardiomyocytes [PDF]
Jichu yixue yu linchuang, 2022 Objective To investigate the effect of propofol (Pro) on cardiomyocyte damage induced by anoxia-reoxygenation through regulating JNK/p38 MAPK pathway. Methods Divided the cells into control group, anoxia-reoxygenation (A/R) group, anoxia-reoxygenation ...
CHEN Si, YANG Fu-guo, PENG Hong-jun, CAO Wei-le, WANG Zhen-yu
doaj +1 more source
Biological Research, 2019 Background Di-N-butyl-phthalate (DBP) is an endocrine disrupting substance. We investigated the adverse effect of DBP on testis of male rat and reveal its potential mechanism of MAPK signaling pathway involved this effect in vivo and in vitro.
Hongyan Wang +3 more
doaj +1 more source
Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death
Frontiers in Cell and Developmental BiologyCell death occurs in various circumstances, such as homeostasis, stress response, and defense, via specific pathways and mechanisms that are regulated by specific activator-induced signal transductions. Among them, Jun N-terminal kinases (JNKs) participate in various aspects, and the recent discovery of JNKs and mitochondrial protein SAB interaction in
Sanda Win, Tin Aung Than, Neil Kaplowitz
openaire +3 more sources
, 2016 (A) Representative Western blot images show cytosolic p-JNK, JNK, p-ERK1/2, ERK1/2, p-p38 MAPK, p38 MAPK, p-Akt, and Akt expression in the cortical penumbra in the Sham, Vehicle, B-FA, P-FA, I-FA, R-FA, and D-FA groups 7 d after reperfusion.
Nou-Ying Tang (535238) +3 more
core +1 more source
Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway
Cellular Physiology and Biochemistry, 2015 Background/Aims: Our previous study confirmed that Loureirin B (LB) can inhibit hypertrophic scar formation. However, the mechanism of LB-mediated inhibition of scar formation is still unknown.
Ting He +8 more
doaj +1 more source
CGZ increases p-JNK levels on primary hippocampal neurons.
, 2013 Cultured hippocampal neurons (15 DIV) were treated with CGZ and GW for 72 h, and cells extracts were prepared for p-JNK and total JNK protein levels detection by western blot.
Deny Cabezas (417322) +6 more
core +1 more source
Journal of Neuroinflammation, 2011 Background We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlying mechanisms are still unclear.
Wang Wen +7 more
doaj +1 more source