Results 1 to 10 of about 119,547 (161)

Inhibition of p38 MAPK after repetitive mTBI ameliorates immune signaling and functional deficits [PDF]

Acta Neuropathologica Communications
Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can lead to long-term neurological impairments. Following mechanical impact, increasing evidence suggests that the brain undergoes an inflammatory cascade ...
Chenxing Li, Martin N. Griffin, Sydney E. Triplett, Anna E. Silverio, Elizabeth Pettit, Alivia M. Rohrer, Jacob P. Callaway, Pranavvarma V. Munagapati, Paul F. Saah, Paul I. Sanz, Felix G. Rivera Moctezuma, Abigail Holberton, Angela Gomez, Erin M. Buckley, Levi B. Wood   +14 more
doaj   +2 more sources

Evidence for the involvement of p38 MAPK activation in barnacle larval settlement. [PDF]

PLoS ONE, 2012
The barnacle Balanus ( = Amphibalanus) amphitrite is a major marine fouling animal. Understanding the molecular mechanism of larval settlement in this species is critical for anti-fouling research.
Li-Sheng He, Ying Xu, Kiyotaka Matsumura, Yu Zhang, Gen Zhang, Shu-Hua Qi, Pei-Yuan Qian   +6 more
doaj   +1 more source

p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice

Neural Plasticity, 2022
Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction.
Kun Hou, Zhi-cheng Xiao, Hai-Long Dai
doaj   +1 more source

Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs. [PDF]

PLoS ONE, 2013
Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonary complications. Ozone reacts with the epithelial lining fluid and airway epithelium to produce reactive oxygen species and lipid peroxidation products ...
Kirsten C Verhein, Francesco G Salituro, Mark W Ledeboer, Allison D Fryer, David B Jacoby   +4 more
doaj   +1 more source

p38 Mitogen-Activated Protein Kinase Inhibition of Mesenchymal Transdifferentiated Tumor Cells in Head and Neck Squamous Cell Carcinoma

Biomedicines, 2023
High mortality in head and neck squamous cell carcinoma (HNSCC) is due to recurrence, metastasis, and radiochemotherapy (RCT) resistance. These phenomena are related to the tumor cell subpopulation undergoing partial epithelial to mesenchymal transition (
Julia Federspiel, Maria do Carmo Greier, Andrea Ladányi, Jozsef Dudas   +3 more
doaj   +1 more source

Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases

Scientific Reports, 2022
p38-MAPK is a stress-response kinase activated by hyperosmolarity. Here we interrogated the pathways involved. We show that p38-MAPK signaling is activated by hyperosmotic stimulation in various solutions, cell types and colonic organoids ...
Zetao Liu, Wael Demian, Avinash Persaud, Chong Jiang, Arohan R. Subramanaya, Daniela Rotin   +5 more
doaj   +1 more source

P38 Mitogen-Activated Protein Kinase Protects Against Retinoblastoma Through Regulating USP22/SIRT1/SOST Axis

Frontiers in Oncology, 2022
Retinoblastoma (RB) is the most common intraocular malignancy in children. It has been previously reported that p38 MAPK is related to the pathogenesis of RB. Here we aim at investigating how p38 MAPK affected RB progression through mediating USP22/SIRT1/
Xiaoming Huang, Xiaoming Huang, Jianfeng Wan, Fei Liu, Yang Liu, Lina Wang, Sidi Zhao, Tong Wu, Tong Wu, Fengyuan Sun, Fengyuan Sun   +10 more
doaj   +1 more source

The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

Heliyon, 2021
The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology ...
El-Shaimaa A. Arafa, Mohamed S. Refaey, Omnia A.M. Abd El-Ghafar, Emad H.M. Hassanein, Ahmed M. Sayed   +4 more
doaj   +1 more source

Contribution of p38 MAPK to the Ameliorating Effect of Enriched Environment on the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion

Cellular Physiology and Biochemistry, 2016
Background/Aims: An enriched environment (EE) ameliorates learning and memory impairments induced by chronic cerebral hypoperfusion, and the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway exerts both beneficial and deleterious effects ...
Yu-Wang Li, Qing-Yun Li, Jin-Hua Wang, Xiao-Lin Xu   +3 more
doaj   +1 more source

Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species

Cellular Physiology and Biochemistry, 2015
Background/Aims: Inhibition of p38 mitogen-activated protein kinase (p38 MAPK) is promising for the treatment of inflammatory disorders, however, the efficacy of p38 MAPK inhibitors in clinical trials is limited so far.
Sarah Fehr, Anke Unger, Elke Schaeffeler, Sonja Herrmann, Stefan Laufer, Matthias Schwab, Wofgang Albrecht   +6 more
doaj   +1 more source