Results 1 to 10 of about 229,819 (298)
The Cx43/p38 MAPK/Runx2 signaling pathway as a potential regulatory axis in insufficient osteogenesis associated with osteoporosis [PDF]
Frontiers in EndocrinologyBackgroundOsteoporosis is characterized by severe osteogenic insufficiency, which severely impairs bone regeneration and repair. Connexin 43 (Cx43) participates in the modulation of osteoblast function, yet its regulatory mechanism linking osteoporosis ...
Dongcheng Peng +7 more
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Chemical degradation of Human p38-MAPK reveals it as a potential host target to combat parasitic infections by Leishmania donovani and Plasmodium falciparum [PDF]
Communications BiologyThe interplay between host and parasite determines parasite burden and disease outcome. Parasite exploits host signaling pathways like p38-MAPK for its survival and pathogenesis. Here we have used NR-7h, a proteolysis-targeting chimera (PROTAC) targeting
Jhalak Singhal +10 more
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Molecules, 2017 P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory diseases. Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, as well as neurodegeneration, and ...
Jong Kil Lee, Nam-Jung Kim
exaly +3 more sources
Evidence for the involvement of p38 MAPK activation in barnacle larval settlement. [PDF]
PLoS ONE, 2012 The barnacle Balanus ( = Amphibalanus) amphitrite is a major marine fouling animal. Understanding the molecular mechanism of larval settlement in this species is critical for anti-fouling research.
Li-Sheng He +6 more
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Neural Plasticity, 2022 Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction.
Kun Hou, Zhi-cheng Xiao, Hai-Long Dai
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Biomedicines, 2023 High mortality in head and neck squamous cell carcinoma (HNSCC) is due to recurrence, metastasis, and radiochemotherapy (RCT) resistance. These phenomena are related to the tumor cell subpopulation undergoing partial epithelial to mesenchymal transition (
Julia Federspiel +3 more
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Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs. [PDF]
PLoS ONE, 2013 Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonary complications. Ozone reacts with the epithelial lining fluid and airway epithelium to produce reactive oxygen species and lipid peroxidation products ...
Kirsten C Verhein +4 more
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Frontiers in Oncology, 2022 Retinoblastoma (RB) is the most common intraocular malignancy in children. It has been previously reported that p38 MAPK is related to the pathogenesis of RB. Here we aim at investigating how p38 MAPK affected RB progression through mediating USP22/SIRT1/
Xiaoming Huang +10 more
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Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases
Scientific Reports, 2022 p38-MAPK is a stress-response kinase activated by hyperosmolarity. Here we interrogated the pathways involved. We show that p38-MAPK signaling is activated by hyperosmotic stimulation in various solutions, cell types and colonic organoids ...
Zetao Liu +5 more
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The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
Heliyon, 2021 The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology ...
El-Shaimaa A. Arafa +4 more
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