Results 41 to 50 of about 119,547 (161)
Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
International Journal of Biological Sciences, 2009 The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent ...
Tina M. Thornton, Mercedes Rincon
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Neurobiology of Disease, 2007 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the selective loss of motor neurons. Stress activated protein kinases (SAPK) have been suggested to play a role in the pathogenesis of ALS.
Maarten Dewil +3 more
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Nuclear Localization of p38 MAPK in Response to DNA Damage
International Journal of Biological Sciences, 2009 p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints.
C. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon
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Journal of Experimental & Clinical Cancer Research, 2012 Background One of the major components of telomerase is the human telomerase reverse transcriptase (hTERT) as the catalytic protein. hTERT mRNA expression are reported to be associated with prognosis and tumor progression in several sarcomas.
Matsuo Toshihiro +6 more
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Journal of Pharmacological Sciences, 2007 Second-hand smoke is associated with increased risk of cardiovascular diseases. So far, little is known about the signaling mechanisms of second-hand smoke-induced vascular dysfunction.
Brad Low, Mei Liang, Jian Fu
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Frontiers in Pharmacology, 2020 Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process activated by lung transplantation and acute lung injury.
Tiantian Wang +11 more
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P38 MAPK and Radiotherapy: Foes or Friends?
Cancers, 2023 Over the last 30 years, the study of the cellular response to ionizing radiation (IR) has increased exponentially. Among the various signaling pathways affected by IR, p38 MAPK has been shown to be activated both in vitro and in vivo, with involvement in key processes triggered by IR-mediated genotoxic insult, such as the cell cycle, apoptosis or ...
Natalia García-Flores +10 more
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PLoS ONE, 2019 Activation of p38 mitogen-activated protein kinase (MAPK) is associated with tissue fibrosis, and inhibition of p38 MAPK can attenuate the progression of fibrosis.
Jeonghwan Lee +5 more
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1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients. [PDF]
PLoS ONE, 2015 Reduced neutrophil apoptosis plays an important role in the pathogenesis of acute exacerbation chronic obstructive pulmonary disease (AECOPD). The p38 mitogen-activated protein kinase (MAPK) signaling pathway is involved in neutrophil apoptosis.
Haihua Yang +13 more
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Journal of the Egyptian Women’s Dermatologic Society, 2020 Background Although the exact pathogenic mechanisms leading to blister formation in pemphigus vulgaris (PV) have not been fully elucidated, intracellular signaling following antibody binding has been found to be necessary for inducing cell-cell ...
Shereen A Sobeih +4 more
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