Results 41 to 50 of about 229,819 (298)

Crosstalk between p38 MAPK and GR Signaling

International Journal of Molecular Sciences, 2022
The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation.
Lisa Zeyen, Ole Morten Seternes, Ingvild Mikkola   +2 more
openaire   +3 more sources

p38 MAPK, Microglial Signaling, and Neuropathic Pain

Molecular Pain, 2007
Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to ...
Ji, Ru-Rong, Suter, Marc
openaire   +5 more sources

The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1 [PDF]

Open Biology, 2013
The signalling pathways downstream of the transforming growth factor beta (TGFβ) family of cytokines play critical roles in all aspects of cellular homeostasis.
Gopal P. Sapkota
doaj   +1 more source

Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

BMC Cancer, 2018
Background The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression of clock-controlled genes ...
Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest, Deborah Bell-Pedersen   +6 more
doaj   +1 more source

Deletion of p38 MAPK in macrophages ameliorates peritoneal fibrosis and inflammation in peritoneal dialysis

Scientific Reports
One of the most common causes of peritoneal dialysis withdrawal is ultrafiltration failure which is characterized by peritoneal membrane thickening and fibrosis.
Akie Ikushima, Takuya Ishimura, Keita P. Mori, Hiroyuki Yamada, Sayaka Sugioka, Akira Ishii, Naohiro Toda, Shoko Ohno, Yukiko Kato, Takaya Handa, Motoko Yanagita, Hideki Yokoi   +11 more
doaj   +1 more source

Inhibition of p38 MAPK suppresses inflammatory cytokine induction by etoposide, 5-fluorouracil, and doxorubicin without affecting tumoricidal activity.

PLoS ONE, 2008
Cancer patients undergoing treatment with systemic cancer chemotherapy drugs often experience debilitating fatigue similar to sickness behavior, a normal response to infection or tissue damage caused by the production of the inflammatory cytokines IL ...
Collin R Elsea, Daniel A Roberts, Brian J Druker, Lisa J Wood   +3 more
doaj   +1 more source

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Iversen, Lars, A Funding, JS Arthur, Johansen, Claus, Kragballe, Knud, BM Bibby, Lilleholt, Louise Langer, Funding, Anne, L Iversen, Bibby, Bo Martin, K Kragballe, C Johansen, Arthur, J. Simon C.; id_orcid, LL Lilleholt   +13 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

p38 MAPK blot.

, 2015
Representative immunoblot of overloaded plantaris tendons demonstrating the ability of SB203580 to prevent the phosphorylation of p38 MAPK. Total p38 MAPK protein is shown as a loading control.
Christopher L. Mendias (702003), Kristoffer B. Sugg (702000), Jonathan P. Gumucio (702002), Andrew J. Schwartz (701998), Justin T. Dzierzawski (702001), Dylan C. Sarver (701999)   +5 more
core   +1 more source

Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation [PDF]

, 2006
Cell-cell contact is essential for appropriate co-ordination of development and it initiates significant signalling events. During myogenesis, committed myoblasts migrate to sites of muscle formation, align and form adhesive contacts that instigate cell ...
Cobb, L.J., Cosgrove, R.A., Pell, J.M., Salih, D.A.M., Kilshaw, P.J., Tripathi, G., Lovett, F.A., Gonzalez, I., Murrell, A.   +8 more
core   +1 more source