Results 61 to 70 of about 119,547 (161)

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome

Pharmaceuticals, 2010
Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process. Cultured primary fibroblast cells from Werner syndrome patients provide a powerful model system to study the link between replicative senescence in vitro and in vivo
Mark C. Bagley, Terence Davis, Paola G. S. Murziani, Caroline S. Widdowson, David Kipling   +4 more
openaire   +3 more sources

Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation

Journal of Transplantation, 2012
In solid organ transplantation, ischemia/reperfusion (IR) injury during organ procurement, storage and reperfusion is an unavoidable detrimental event for the graft, as it amplifies graft inflammation and rejection.
Giuseppe Vassalli, Giuseppina Milano, Tiziano Moccetti   +2 more
doaj   +1 more source

TRPV4 is involved in NLRP3 and NLRP1 inflammasomes activation after pilocarpine-induced status epilepticus in mice

Cellular and Molecular Life Sciences
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain-containing 1 (NLRP1) and NLRP3 inflammasomes are activated in temporal lobe epilepsy (TLE), leading to neuroinflammation, pyroptosis, and neuronal injury.
Lihan Liu, Guowen Zhang, Yu Xu, Xiaolin Wang, Sha Sha, Chunfeng Wu, Wei Li, Lei Chen   +7 more
doaj   +1 more source

Electroacupuncture improves learning-memory ability in diabetic rats with cognitive impairment via inhabitating proinflammatory cytokine production through p38 MAPK and STAT3 pathway

针刺研究, 2020
Objective To investigate the effect of electroacupuncture(EA) on the p38 mitogen-activated protein kinase(p38 MAPK) and signal transducer and activator of transcription 3(STAT3) pathway in hippocampus and frontal cortex of diabetic rats with cognitive ...
YUAN Ai-hong, CAO Jiang-peng, YANG Jun, SONG Xiao-ge, ZHA Bi-xiang, GAO Zhi-qun, YE Min   +6 more
doaj  

Critical Role of p38α MAPK Subclass in the Development of Pain Hypersensitivity After Hind Paw Incision

Journal of Pain Research
Daiki Ishikawa,1 Shunsuke Yamakita,1 Kentaro Oh-Hashi,2– 4 Fumimasa Amaya1 1Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University,
Ishikawa D, Yamakita S, Oh-Hashi K, Amaya F   +3 more
doaj  

p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential

Immunity & Ageing
Background In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (SASP) with inflammatory and osteoclastogenic potential, favoring inflammation and bone loss.
Luis González-Osuna, Sandra Yasuyo Fukada, María Paz Hernández-Cáceres, Patricia Luz-Crawford, Cristian Cortez, Carolina Rojas, Paola Carvajal, Alfredo Sierra-Cristancho, Rolando Vernal   +8 more
doaj   +1 more source

Effects of P38 MAPK Pathway Inhibition on the Metabolism of Periodontal Ligament Fibroblasts During Inflammation. [PDF]

J Cell Mol Med
Qian C, Gu Y, Gao F, Xu Z, Li J, Liu S, He R, Zhong L, Wang J.   +8 more
europepmc   +1 more source

Dapagliflozin binds PRMT7 to inhibit p38 MAPK phosphorylation and macrophage foam cell formation in atherosclerosis. [PDF]

iScience
Fang Y, Li S, Qin C, Chou Y, Sun N, Ma Y, Zhou Y, Li H, Feng H, Yuan X, Ye H, Wu X, Kang N, Chen H, Gao L, Cao F.   +15 more
europepmc   +1 more source

p38 MAPK orchestrates cross-tissue potassium homeostasis for survival. [PDF]

Nat Commun
Huang R, Hu F, Li Y, Gao Q, Huang J, Wang J, Lu W, Wang L, Fang Y, Blackwell TK, Wu Z.   +10 more
europepmc   +1 more source

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress. [PDF]

Int J Mol Med
Takebe K, Nishiyama T, Hayashi S, Hashimoto S, Fujishiro T, Kanzaki N, Kawakita K, Iwasa K, Kuroda R, Kurosaka M.   +9 more
europepmc   +1 more source