Results 61 to 70 of about 229,819 (298)
Frontiers in Cell and Developmental BiologyThe mammalian p38 MAPK pathway plays a vital role in transducing extracellular environmental stresses into numerous intracellular biological processes.
Gang Du +7 more
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Heliyon, 2019 We investigated the differentiation and activation of p38 MAPK induced by contrast bath in drug-hypersensitive PC12m3 mutant cells. The rate of neurite outgrowth in PC12m3 cells induced by contrast bath was much higher than that induced by warming or ...
Hirotoshio Motoda +5 more
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Modification of collagen by 3-deoxyglucosone alters wound healing through differential regulation of p38 MAP kinase. [PDF]
PLoS ONE, 2011 BACKGROUND: Wound healing is a highly dynamic process that requires signaling from the extracellular matrix to the fibroblasts for migration and proliferation, and closure of the wound. This rate of wound closure is impaired in diabetes, which may be due
Danielle T Loughlin, Carol M Artlett
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iScience, 2023 Summary: Anaplasma phagocytophilum modulates various cell signaling pathways in mammalian cells for its survival. In this study, we report that A. phagocytophilum modulates tick tryptophan pathway to activate arthropod p38 MAP kinase for the survival of ...
Prachi Namjoshi +3 more
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Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction
Advanced Materials, EarlyView.The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu +2 more
wiley +1 more source
Knockdown of chemerin decreased proteins associated with p-p38-MAPK.
, 2016 Protein levels of NF-κBp65 (A), PCNA (B), p-ERK 1/2 (C), and p-p38-MAPK (D) in VSMCs and carotid tissues were up-regulated by PDGF-BB (20ng/mL) or carotid angioplasty. Up-regulation of these factors was significantly inhibited by knockdown of chemerin in
Wei Xiong (58411) +7 more
core +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
International Journal of Biological Sciences, 2009 The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent ...
Tina M. Thornton, Mercedes Rincon
doaj
Advanced Science, EarlyView.The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo +20 more
wiley +1 more source
EV71 infection triggers p38 MAPK phosphorylation downstream of MINK.
, 2015 Western blot analysis was performed to assess the levels of phosphorylated p38 MAPK (phospho-p38) at 0, 2, 4, 6, 8, 10 and 12hpi. Total p38 (t-p38) was probed as an internal control for p38 MAPK protein expression and β-actin was used as a loading ...
Bryan Kit Teck Ong (699835) +2 more
core +1 more source