Results 1 to 10 of about 4,528,027 (196)
P38 mitogen-activated protein kinase and Parkinson’s disease [PDF]
Translational Neuroscience, 2018 Parkinson’s disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson’s disease are not fully understood, considerable evidence suggests that neuro-inflammation ...
He Jianying +4 more
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Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition [PDF]
Scientific Reports, 2021 Natriuretic peptides exert multiple effects by binding to natriuretic peptide receptors (NPRs). Osteocrin (OSTN) binds with high affinity to NPR-C, a clearance receptor for natriuretic peptides, and inhibits degradation of natriuretic peptides and ...
Takaya Handa +12 more
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Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and DifferentiationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background and Aims: The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. An imbalance in this highly regimented process within the intestinal crypts is associated with several intestinal pathologies ...
Chang Li +11 more
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The significance of ERK5 catalytic-independent functions in disease pathways
Frontiers in Cell and Developmental Biology, 2023 Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family.
Nhat-Tu Le
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ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
Cells, 2020 : Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
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Scientific Reports, 2023 Mitogen-activated protein kinase (MAPK) p38 is a central regulator of intracellular signaling, driving physiological and pathological pathways. With over 150 downstream targets, it is predicted that spatial positioning and the availability of cofactors ...
Jeremy C. Burton +2 more
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p38 mitogen‐activated protein kinase: Functions and targeted therapy in diseases
MedComm – Oncology, 2023 P38 mitogen‐activated protein kinase (p38MAPK) is a multifunctional protein kinase that plays an important role in human normal physiological activities and a variety of major diseases, and its signaling pathway affects a variety of regulatory factors in
Qinwen Zheng +10 more
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Journal of Pharmacological Sciences, 2004 Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 ...
Yoshikage Muroi +4 more
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Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model
European Journal of Histochemistry, 2022 Cisplatin (CDDP) has been widely used in cancer therapy, but it has been linked to side effects such as nephrotoxicity. Crocin is a carotenoid found in crocus and gardenia flowers that has been shown to have anti-oxidant properties, inhibit tumor growth,
Qichao Yin, Hua Xiong
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Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]
PLoS ONE, 2008 Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay +9 more
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