Results 1 to 10 of about 84,218 (160)
P38 mitogen-activated protein kinase and Parkinson’s disease [PDF]
Translational Neuroscience, 2018 Parkinson’s disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson’s disease are not fully understood, considerable evidence suggests that neuro-inflammation ...
He Jianying +4 more
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Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. [PDF]
PLoS ONE, 2015 Gaucher's disease is caused by defects in acid β-glucosidase 1 (GBA1) and has been also proposed as an inflammatory disease. GBA1 cleaves glucosylceramide to form ceramide, an established bioactive lipid, and defects in GBA1 lead to aberrant accumulation
Kazuyuki Kitatani +8 more
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Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition [PDF]
Scientific Reports, 2021 Natriuretic peptides exert multiple effects by binding to natriuretic peptide receptors (NPRs). Osteocrin (OSTN) binds with high affinity to NPR-C, a clearance receptor for natriuretic peptides, and inhibits degradation of natriuretic peptides and ...
Takaya Handa +12 more
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Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and DifferentiationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background and Aims: The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. An imbalance in this highly regimented process within the intestinal crypts is associated with several intestinal pathologies ...
Chang Li +11 more
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The significance of ERK5 catalytic-independent functions in disease pathways
Frontiers in Cell and Developmental Biology, 2023 Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family.
Nhat-Tu Le
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Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases [PDF]
Molecular and Cellular Biology, 2002 Nuclear factor of activated T cells (NFAT) is implicated in multiple biological processes, including cytokine gene expression, cardiac hypertrophy, and adipocyte differentiation. A conserved NFAT homology domain is identified in all NFAT members.
Teddy T C, Yang +4 more
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Crystal Structure of p38 Mitogen-activated Protein Kinase [PDF]
Journal of Biological Chemistry, 1996 p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses. The crystal structure of the apo, unphosphorylated form of p38 kinase has been solved at 2.3 A resolution. The fold and topology of p38 is similar to ERK2 (Zhang, F., Strand, A., Robbins, D.,
K P, Wilson +7 more
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ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
Cells, 2020 : Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
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Scientific Reports, 2023 Mitogen-activated protein kinase (MAPK) p38 is a central regulator of intracellular signaling, driving physiological and pathological pathways. With over 150 downstream targets, it is predicted that spatial positioning and the availability of cofactors ...
Jeremy C. Burton +2 more
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p38 mitogen‐activated protein kinase: Functions and targeted therapy in diseases
MedComm – Oncology, 2023 P38 mitogen‐activated protein kinase (p38MAPK) is a multifunctional protein kinase that plays an important role in human normal physiological activities and a variety of major diseases, and its signaling pathway affects a variety of regulatory factors in
Qinwen Zheng +10 more
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