Results 31 to 40 of about 84,309 (251)
Journal of Pharmacological Sciences, 2007 Although spleen tyrosine kinase (Syk) has crucial roles in various cells, its function on vascular smooth muscle contraction has not been determined. In the present study, we performed experiments to determine if Syk contributes to the endothelin-1 (ET-1)
Hwan Myung Lee +8 more
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Journal of Pharmacological Sciences, 2006 .: Nitric oxide (NO) induces apoptosis in various cells lines, while activation of the NO/cGMP signaling pathway prevents apoptosis induced by diverse stimuli, including NO.
Yoshioka Yasuhiro +2 more
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Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors [PDF]
Molecular and Cellular Biology, 1999 Mitogen-activated protein (MAP) kinase-mediated signalling to the nucleus is an important event in the conversion of extracellular signals into a cellular response. However, the existence of multiple MAP kinases which phosphorylate similar phosphoacceptor motifs poses a problem in maintaining substrate specificity and hence the correct biological ...
Yang S-H, Galanis A, Sharrocks AD
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Adiponectin impairs chicken preadipocytes differentiation through p38 MAPK/ATF-2 and TOR/p70 S6 kinase pathways. [PDF]
PLoS ONE, 2013 Adiponectin is a protein hormone secreted exclusively by adipocytes that plays an important role in the modulation of glucose and lipid metabolism.
Jun Yan, Lu Gan, Di Chen, Chao Sun
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p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
Cell Stress, 2021 Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun +6 more
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The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution [PDF]
Proceedings of the National Academy of Sciences, 1997 The structure of mitogen-activated protein (MAP) kinase p38 has been solved at 2.1-Å to an R factor of 21.0%, making p38 the second low activity MAP kinase solved to date. Although p38 is topologically similar to the MAP kinase ERK2, the phosphorylation Lip (a regulatory loop near the active ...
Z, Wang +5 more
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Al-Mustansiriyah Journal of Pharmaceutical SciencesBreast cancer is a diverse disease with high mortality rates, often due to metastasis. Breast cancer subtypes vary by the expression of progesterone receptor, human epidermal growth factor receptor 2, and estrogen receptor.
Mustafa Abdul Jabbar a Qader +3 more
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A central role for p38 MAPK in the early transcriptional response to stress
BMC Biology, 2010 The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in ...
Whitmarsh Alan J
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p38 mitogen-activated protein kinases: their role in carcinogenesis [PDF]
Revista de Oncología, 2003 [EN]: The members of the p38 subfamily of Mitogen-Activated Protein Kinases (MAPKs) are a versatile group of proteins, that function as signal transducers involved in key cellular functions. Initially, p38 MAPKs were associated with inflammatory and cellular stress responses and, as such, p38 has been an important target for anti-inflammatory therapies.
Sanz-Moreno, Victoria, Crespo, Piero
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Journal of Pharmacological Sciences, 2007 In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic ...
Hwan Myung Lee +11 more
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