Results 31 to 40 of about 4,528,027 (196)

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]

, 2010
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo, Weiguo Zou, Shim, Jae-Hyuck, Hu, Dorothy, Lotinun, Sutada, Glimcher, Laurie H., Arthur, Simon; id_orcid, Michael D. Schneider, Yasuyo Sano, Min Xie, Matthew B. Greenblatt, Laurie H. Glimcher, Jae-Hyuck Shim, Roger Davis, Xie, Min, Sano, Yasuyo, Despina Sitara, Schweitzer, Michelle, Park, Jin Mo, Schneider, Michael D., Gygi, Steven, Greenblatt, Matthew B., Baron, Roland, Simon Arthur, Zou, Weiguo, Jin Mo Park, Michelle Schweitzer, Davis, Roger, Roland Baron, Sitara, Despina, Sutada Lotinun, Dorothy Hu, Bo Zhai, Steven Gygi   +33 more
core   +1 more source

Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]

, 2006
Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb, Krell, Hans-Willi, Kolb, Helmut, Heidinger, Michael, Michael Heidinger, Hans-Willi Krell, Marianne Jochum, Jochum, Marianne, Christian Ries, Ries, Christian   +9 more
core   +1 more source

Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]

PLoS ONE, 2013
Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda, Kunihiro Fukushima, Ryotaro Omichi, Shin Kariya, Kazunori Nishizaki   +4 more
doaj   +1 more source

Dynamic activation and regulation of the mitogen-activated protein kinase p38 [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance The physical basis for the regulation of protein MAP kinases is key to understanding their role in cellular signaling in human biology and disease. However, the biochemical events that lead to MAPK activation are not well understood. Here, using biomolecular NMR dynamics measurements, we show that kinase activation is not
Ganesan Senthil Kumar, Michael W. Clarkson, Micha B. A. Kunze, Daniele Granata, A. Joshua Wand, Kresten Lindorff-Larsen, Rebecca Page, Wolfgang Peti   +7 more
openaire   +3 more sources

Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization [PDF]

, 2001
Trophic factor withdrawal induces cell death by mechanisms that are incompletely understood. Previously we reported that withdrawal of interleukin-7 (IL-7) or IL-3 produced a rapid intracellular alkalinization, disrupting mitochondrial metabolism and ...
Li, Aiqun Q., Moor, Andrea N., Fisher, Robert J., Durum, Scott K., Ferris, Douglas K., Muegge, Kathrin, Khaled, Annette R., Fliegel, Larry, Kim, Kyungjae   +8 more
core   +1 more source

Capsaicin Acts Through Reducing P38 MAPK-Dependent Thymidylate Synthase Expression to Enhance 5-Fluorouracil-Induced Cytotoxicity in Human Lung Cancer Cells

Natural Product Communications, 2021
Capsaicin, an ingredient of green and red bell peppers, shows anticancer activity in several malignant cell lines. Thymidylate synthase (TS) is a well-validated anticancer drug target in non-small cell lung cancer (NSCLC) cells.
Chun-Liang Tung, Jyh-Cheng Chen, Jen-Chung Ko, Li-Ling Liu, Chin-Cheng Chien, I-Hsiang Huang, Yong-Cing Tsao, Hsiang-Hung Cheng, Tzu-Ying Chen, Ting-Chuan Yen, Yun-Wei Lin   +10 more
doaj   +1 more source

Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger

Journal of Pharmacological Sciences, 2010
The mechanism for sustained Ca2+ influx activated by G protein–coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a ...
Tsunaki Higa, Takahiro Horinouchi, Hiroyuki Aoyagi, Hiroshi Asano, Tadashi Nishiya, Arata Nishimoto, Ikunobu Muramatsu, Soichi Miwa   +7 more
doaj   +1 more source

p38 Mitogen-Activated Protein Kinases on the Body Surface – A Function for p38δ [PDF]

Journal of Investigative Dermatology, 2003
The p38 family of mitogen-activated protein kinases includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress.
Eckert, Richard L., Efimova, Tatiana, Balasubramanian, Sivaprakasam, Crish, James F., Bone, Frederic, Dashti, Shervin   +5 more
openaire   +2 more sources

Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways

Journal of Ginseng Research, 2016
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin, Wei Yang, Dongxu Feng, Xinwen Wang, Muyao Qi, Tianxin Du, Hongzhi Sun, Shufang Wu   +7 more
doaj   +1 more source

Role of p38 Mitogen-Activated Protein Kinases in Preconditioning [PDF]

Circulation Research, 2000
Preconditioning, the phenomenon whereby brief episodes of ischemia or pharmacological agents protect the myocardium against subsequent ischemic injury, consists of an early and a late phase.1 The early phase develops immediately and disappears within 1 to 2 hours of ischemic preconditioning stimulus, whereas the late phase, also known as the “second ...
P, Ping, E, Murphy
openaire   +2 more sources