Results 21 to 30 of about 4,528,027 (196)
C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]
, 2003 Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B. +4 more
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Journal of Pharmacological Sciences, 2007 Second-hand smoke is associated with increased risk of cardiovascular diseases. So far, little is known about the signaling mechanisms of second-hand smoke-induced vascular dysfunction.
Brad Low, Mei Liang, Jian Fu
doaj +1 more source
A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway
Redox Biology, 2020 The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in the cellular response to various stresses and its deregulation accompanies pathological conditions such as cancer and chronic inflammation.
Ana G. Barata, Tobias P. Dick
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Role of p38 mitogen‐activated protein kinase in cardiac remodelling [PDF]
British Journal of Pharmacology, 2007 Background and purpose:Mitogen‐activated protein kinases (MAPK) are centrally involved in several mechanisms important for heart failure such as apoptosis, activation of inflammatory responses and cell proliferation. We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after ...
S, Frantz +8 more
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Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]
, 2008 We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Vollmar, Angelika M. +2 more
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Diverse physiological functions for dual-specificity MAP kinase phosphatases [PDF]
, 2006 A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase (MAPK) family members in mammals.
Keyse, Stephen M, Dickinson, Robin J
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Journal of Pharmacological Sciences, 2009 .: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations ...
Sung Lyea Park +6 more
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Cell Death and Disease, 2021 Metastasis-associated protein 2 (MTA2) is a transcription factor that is highly associated with matrix metalloproteinase 12 (MMP12). Thus, we hypothesized that MTA2 may regulate MMP12 expression and is involved in cervical cancer metastasis.
Chia-Liang Lin +6 more
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Frontiers in Physiology, 2021 Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li +8 more
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p38 Mitogen-Activated Protein Kinase and Hematologic Malignancies
Archives of Pathology & Laboratory Medicine, 2009 Abstract Context. —p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in responses ranging from apoptosis to cell cycle, induction of expression of cytokine genes, and differentiation. This plethora of activators conveys the complexity of the p38 pathway.
Yongdong, Feng +2 more
openaire +2 more sources