Results 21 to 30 of about 84,309 (251)
Frontiers in Physiology, 2021 Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li +8 more
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Dynamic activation and regulation of the mitogen-activated protein kinase p38 [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance The physical basis for the regulation of protein MAP kinases is key to understanding their role in cellular signaling in human biology and disease. However, the biochemical events that lead to MAPK activation are not well understood. Here, using biomolecular NMR dynamics measurements, we show that kinase activation is not
Ganesan Senthil Kumar +7 more
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p38 Mitogen-Activated Protein Kinase and Hematologic Malignancies
Archives of Pathology & Laboratory Medicine, 2009 Abstract Context. —p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in responses ranging from apoptosis to cell cycle, induction of expression of cytokine genes, and differentiation. This plethora of activators conveys the complexity of the p38 pathway.
Yongdong, Feng +2 more
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Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
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Natural Product Communications, 2021 Capsaicin, an ingredient of green and red bell peppers, shows anticancer activity in several malignant cell lines. Thymidylate synthase (TS) is a well-validated anticancer drug target in non-small cell lung cancer (NSCLC) cells.
Chun-Liang Tung +10 more
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Journal of Pharmacological Sciences, 2010 The mechanism for sustained Ca2+ influx activated by G protein–coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a ...
Tsunaki Higa +7 more
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p38 Mitogen-Activated Protein Kinases on the Body Surface – A Function for p38δ [PDF]
Journal of Investigative Dermatology, 2003 The p38 family of mitogen-activated protein kinases includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress.
Eckert, Richard L. +5 more
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Journal of Ginseng Research, 2016 Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin +7 more
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Role of p38 Mitogen-Activated Protein Kinases in Preconditioning [PDF]
Circulation Research, 2000 Preconditioning, the phenomenon whereby brief episodes of ischemia or pharmacological agents protect the myocardium against subsequent ischemic injury, consists of an early and a late phase.1 The early phase develops immediately and disappears within 1 to 2 hours of ischemic preconditioning stimulus, whereas the late phase, also known as the “second ...
P, Ping, E, Murphy
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Parasite, 2003 Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T.
Valère A. +5 more
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