Results 11 to 20 of about 84,309 (251)

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Calcineurin Contributes to the Enhancing Effect of Adenosine on Nerve Growth Factor-Induced Neurite Outgrowth via the Decreased Duration of p38 Mitogen-Activated Protein Kinase Phosphorylation

Journal of Pharmacological Sciences, 2004
Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 ...
Yoshikage Muroi, Toshiaki Ishii, Kentarou Teramoto, Masatoshi Hori, Masakazu Nishimura   +4 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model

European Journal of Histochemistry, 2022
Cisplatin (CDDP) has been widely used in cancer therapy, but it has been linked to side effects such as nephrotoxicity. Crocin is a carotenoid found in crocus and gardenia flowers that has been shown to have anti-oxidant properties, inhibit tumor growth,
Qichao Yin, Hua Xiong
doaj   +1 more source

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]

PLoS ONE, 2008
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi   +9 more
doaj   +1 more source

p38 Mitogen-Activated Protein Kinase Mediates Sidestream Cigarette Smoke-Induced Endothelial Permeability

Journal of Pharmacological Sciences, 2007
Second-hand smoke is associated with increased risk of cardiovascular diseases. So far, little is known about the signaling mechanisms of second-hand smoke-induced vascular dysfunction.
Brad Low, Mei Liang, Jian Fu
doaj   +1 more source

A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway

Redox Biology, 2020
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in the cellular response to various stresses and its deregulation accompanies pathological conditions such as cancer and chronic inflammation.
Ana G. Barata, Tobias P. Dick
doaj   +1 more source

Role of p38 mitogen‐activated protein kinase in cardiac remodelling [PDF]

British Journal of Pharmacology, 2007
Background and purpose:Mitogen‐activated protein kinases (MAPK) are centrally involved in several mechanisms important for heart failure such as apoptosis, activation of inflammatory responses and cell proliferation. We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after ...
S, Frantz, T, Behr, K, Hu, D, Fraccarollo, J, Strotmann, E, Goldberg, G, Ertl, C E, Angermann, J, Bauersachs   +8 more
openaire   +2 more sources

Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells

Journal of Pharmacological Sciences, 2009
.: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations ...
Sung Lyea Park, You-Mie Kim, Jin-Hee Ahn, Soo Hwan Lee, Eun Joo Baik, Chang-Hyun Moon, Yi-Sook Jung   +6 more
doaj   +1 more source

MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis

Cell Death and Disease, 2021
Metastasis-associated protein 2 (MTA2) is a transcription factor that is highly associated with matrix metalloproteinase 12 (MMP12). Thus, we hypothesized that MTA2 may regulate MMP12 expression and is involved in cervical cancer metastasis.
Chia-Liang Lin, Tsung-Ho Ying, Shun-Fa Yang, Hui-Ling Chiou, Yong-Syuan Chen, Shao-Hsuan Kao, Yi-Hsien Hsieh   +6 more
doaj   +1 more source