A central role for p38 MAPK in the early transcriptional response to stress
BMC Biology, 2010 The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in ...
Whitmarsh Alan J
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p38 mitogen-activated protein kinases: their role in carcinogenesis [PDF]
Revista de Oncología, 2003 [EN]: The members of the p38 subfamily of Mitogen-Activated Protein Kinases (MAPKs) are a versatile group of proteins, that function as signal transducers involved in key cellular functions. Initially, p38 MAPKs were associated with inflammatory and cellular stress responses and, as such, p38 has been an important target for anti-inflammatory therapies.
Sanz-Moreno, Victoria, Crespo, Piero
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Journal of Pharmacological Sciences, 2007 In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic ...
Hwan Myung Lee +11 more
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Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]
, 2000 The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David +16 more
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New inhibitors of p38 mitogen-activated protein kinase: Repurposing of existing drugs with deep learning [PDF]
, 2021 P38-alpha (MAPK14) is a protein kinase that is implicated in the pathological mechanisms of BAG3 P209L myofibrillar myopathy, cancers, Alzheimer’s disease and other diseases like rheumatoid arthritis.
Valentina, Kouznetsova +2 more
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An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion. [PDF]
PLoS ONE, 2013 BACKGROUND AND OBJECTIVES: Platelets during storage undergo diverse alterations collectively known as the platelet storage lesion, including metabolic, morphological, functional and structural changes.
Andrey Skripchenko +5 more
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Molecular Cloning and Characterization of aDrosophila p38 Mitogen-activated Protein Kinase [PDF]
Journal of Biological Chemistry, 1998 A mitogen-activated protein kinase (MAPK) has been cloned and sequenced from a Drosophila neoplasmic l(2)mbn cell line. The cDNA sequence analysis showed that this Drosophila kinase is a homologue of mammalian p38 MAPK and the yeast HOG1 gene and thus was referred to as Dp38.
S J, Han, K Y, Choi, P T, Brey, W J, Lee
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, 2009 Mitogen- and stress-activated protein kinase (MSK1) palys; a crucial role in the regulation of transcription downstream of extracellular-signal-regulated kinase1/2 (ERK1/2) and mitogen-activated protein kinase p38.
Guanghui Han +20 more
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EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells [PDF]
, 2009 The EGF-related protein EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1) has been shown to promote tumor growth in human adenocarcinoma.
Jauch, Karl-Walter +8 more
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When kinases meet mathematics: the systems biology of MAPK signalling [PDF]
, 2005 The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified ...
Calder, M., Kolch, W., Gilbert, D.
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