Uncovering the Role of p38 Family Members in Adipose Tissue Physiology
Frontiers in Endocrinology, 2020 The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial ...
Magdalena Leiva +4 more
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Phospholipase C-β 2 interacts with mitogen-activated protein kinase kinase 3
, 2002 Phospholipase C (PLC)-β enzymes (isoenzymes β1–β4) are activated by G protein subunits, leading to the generation of intracellular messengers which mobilize calcium and activate protein kinase C.
Barr, A.J. +3 more
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MAP3K1: A Multifunctional Kinase at the Crossroads of Cancer Progression and Tumor Suppression
CellsMitogen-activated protein kinase kinase kinase 1 (MAP3K1) possesses dual enzymatic functions, i.e., kinase and E3 ubiquitin ligase activities, orchestrating proliferation, survival, apoptosis, DNA damage response, and immune modulation.
Lelisse T. Umeta, Amarnath Natarajan
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Journal of Ginseng Research, 2018 Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated.
Min Jung Lee +4 more
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Role of ether-linked lysophosphatidic acids in ovarian cancer cells
Journal of Lipid Research, 2002 Naturally occurring alkyl- and alkenyl-lysophosphatidic acids (al-LPAs) are detected and elevated in ovarian cancer ascites compared with ascites from non-malignant diseases.
Jun Lu +4 more
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Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells. [PDF]
PLoS ONE, 2014 We previously reported that bupivacaine induces reactive oxygen species (ROS) generation, p38 mitogen-activated protein kinase (MAPK) activation and nuclear factor-kappa B activation, resulting in an increase in expression of WD repeat-containing protein
Lei Huang +8 more
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Mechanisms of Regulation of Oligodendrocyte Development by p38 Mitogen-Activated Protein Kinase [PDF]
The Journal of Neuroscience, 2010 Many extracellular and intrinsic factors regulate oligodendrocyte development, but their signaling pathways remain poorly understood. Although the p38 mitogen-activated protein kinase (MAPK)-dependent pathway is implicated in oligodendrocyte progenitor cell (OPC) lineage progression, its molecular targets involved in myelinogenesis are mostly ...
Li-Jin, Chew +3 more
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Untersuchungen zur Regulierung und Funktion der Mitogen-aktivierten Proteinkinase ERK5 = Regulation and Function of the Mitogen-activated Protein Kinase ERK5 [PDF]
, 2003 Mitogen activated protein kinases (MAPKs) are found in all eukaryotic cells and represent crucial elements in the signal transduction from the plasma membrane to the nucleus.
Buschbeck, Marcus
core
Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. [PDF]
PLoS ONE, 2013 Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined ...
Gerardo A Morfini +19 more
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Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase [PDF]
Journal of Biological Chemistry, 1997 The p38 mitogen-activated protein kinases (MAPK) are activated by cellular stresses and play an important role in regulating gene expression. We have isolated a cDNA encoding a novel protein kinase that has significant homology (57% amino acid identity) to human p38alpha/CSBP.
X S, Wang +12 more
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