Results 51 to 60 of about 119,547 (161)

AKT-independent activation of p38 MAP kinase promotes vascular calcification

Redox Biology, 2018
Vascular calcification is prevalent in patients with atherosclerosis, and oxidative stress promotes pathogenesis of atherosclerosis. We have previously reported that activation of AKT by oxidative stress induces vascular calcification.
Youfeng Yang, Yong Sun, Jianye Chen, Wayne E. Bradley, Louis J. Dell’Italia, Hui Wu, Yabing Chen   +6 more
doaj   +1 more source

Ketamine reduces the induced spinal p38 MAPK and pro-inflammatory cytokines in a neuropathic rats [PDF]

Korean Journal of Anesthesiology, 2014
BackgroundNeuropathic rats created by spinal nerve ligation are known to show higher levels of p38, c-Jun NH2-terminal kinase, and extracellular signal-regulated kinase p44/42 (ERK 1/2) of the mitogen-activated protein kinases (MAPKs).
So-Young Kwon, Jae Hwa Yeom, Jin-Deok Joo   +2 more
doaj   +1 more source

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

Neurobiology of Disease, 2013
The p38 mitogen-activated protein kinase (MAPK) isoforms are phosphorylated by a variety of stress stimuli in neurodegenerative disease and act as upstream activators of myriad pathogenic processes.
Jason D. Dapper, Samuel D. Crish, Iok-Hou Pang, David J. Calkins   +3 more
doaj   +1 more source

Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B signaling

Molecular Pain, 2023
Resolvin D1 (RvD1) suppresses inflammatory, postoperative, and neuropathic pain. The present study assessed the roles and mechanisms of RvD1 in mechanical allodynia after burn injury.
Xiaona Zhao MM, Xinxin Li MM, Huiling Guo MM, Panmei Liu MM, Minyu Ma MD, Yanping Wang PhD   +5 more
doaj   +1 more source

Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-κB in rats with trigeminal neuropathic pain

Molecular Pain, 2011
Background We investigated the differential regulation of p-p38 MAPK or p-NF-κB in male Sprague-Dawley rats with inferior alveolar nerve injury resulting from mal-positioned dental implants. For this purpose, we characterized the temporal expression of p-
Lee Min K, Han Seung R, Park Min K, Kim Min J, Bae Yong C, Kim Sung K, Park Jae S, Ahn Dong K   +7 more
doaj   +1 more source

Intervention of Electroacupuncture on Spinal p38 MAPK/ATF-2/VR-1 Pathway in Treating Inflammatory Pain Induced by CFA in Rats

Molecular Pain, 2013
Background Previous studies have demonstrated that p38 MAPK signal transduction pathway plays an important role in the development and maintenance of inflammatory pain. Electroacupuncture (EA) can suppress the inflammatory pain. However, the relationship
Jian-Qiao Fang, Jun-Ying Du, Yi Liang, Jun-Fan Fang   +3 more
doaj   +1 more source

Neuronal p38 MAPK Signaling Contributes to Cisplatin-Induced Peripheral Neuropathy

Antioxidants
This study investigates the role of p38 mitogen-activated protein kinase (MAPK) activation in dorsal root ganglion (DRG) neurons in the development and progression of chemotherapy-induced peripheral neuropathy (CIPN).
Yugal Goel, Donovan A. Argueta, Kristen Peterson, Naomi Lomeli, Daniela A. Bota, Kalpna Gupta   +5 more
doaj   +1 more source

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

Molecules, 2017
P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory diseases. Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, as well as neurodegeneration, and ...
Jong Kil Lee, Nam-Jung Kim
doaj   +1 more source

The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

International Journal of Endocrinology, 2016
Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
Li Peng, Jie Li, Yixing Xu, Yangtian Wang, Hong Du, Jiaqing Shao, Zhimin Liu   +6 more
doaj   +1 more source

The protective role of microRNA-21 against coxsackievirus B3 infection through targeting the MAP2K3/P38 MAPK signaling pathway

Journal of Translational Medicine, 2019
Background The P38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in CVB3-induced diseases. We previously demonstrated microRNA-21 has potential inhibitory effect on the MAP2K3 which locates upstream of P38 MAPK and was ...
Feng He, Zonghui Xiao, Hailan Yao, Sen Li, Miao Feng, Wei Wang, Zhewei Liu, Zhuo Liu, Jianxin Wu   +8 more
doaj   +1 more source