Results 31 to 40 of about 119,547 (161)

Inhibition of p38 MAPK suppresses inflammatory cytokine induction by etoposide, 5-fluorouracil, and doxorubicin without affecting tumoricidal activity.

PLoS ONE, 2008
Cancer patients undergoing treatment with systemic cancer chemotherapy drugs often experience debilitating fatigue similar to sickness behavior, a normal response to infection or tissue damage caused by the production of the inflammatory cytokines IL ...
Collin R Elsea, Daniel A Roberts, Brian J Druker, Lisa J Wood   +3 more
doaj   +1 more source

Deletion of p38 MAPK in macrophages ameliorates peritoneal fibrosis and inflammation in peritoneal dialysis

Scientific Reports
One of the most common causes of peritoneal dialysis withdrawal is ultrafiltration failure which is characterized by peritoneal membrane thickening and fibrosis.
Akie Ikushima, Takuya Ishimura, Keita P. Mori, Hiroyuki Yamada, Sayaka Sugioka, Akira Ishii, Naohiro Toda, Shoko Ohno, Yukiko Kato, Takaya Handa, Motoko Yanagita, Hideki Yokoi   +11 more
doaj   +1 more source

RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

Journal of Experimental & Clinical Cancer Research, 2020
Background Inhibition of p38 MAPK signalling leads to glioblastoma multiform (GBM) tumourigenesis. Nevertheless, the molecular mechanism that induces p38 MAPK signalling pathway silencing during GBM genesis has yet to be determined.
Yang Xu, Qian Sun, Fan’en Yuan, Huimin Dong, Huikai Zhang, Rongxin Geng, Yangzhi Qi, Xiaoxing Xiong, Qianxue Chen, Baohui Liu   +9 more
doaj   +1 more source

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway

American Journal of Physiology-Endocrinology and Metabolism, 2011
The adaptor protein APPL1 mediates the stimulatory effect of adiponectin on p38 mitogen-activated protein kinase (MAPK) signaling, yet the underlying mechanism remains unclear. Here we show that, in C2C12 cells, overexpression or suppression of APPL1 enhanced or suppressed, respectively, adiponectin-stimulated p38 MAPK upstream kinase cascade ...
Xiaoban, Xin, Lijun, Zhou, Caleb M, Reyes, Feng, Liu, Lily Q, Dong   +4 more
openaire   +3 more sources

Inhibition of Nucleoside Transport by p38 MAPK Inhibitors [PDF]

Journal of Biological Chemistry, 2002
While investigating the ability of p38 MAPK to regulate cytarabine (Ara C)-dependent differentiation of erythroleukemia K562 cells, we observed effects that indicated that the imidazoline class of p38 MAPK inhibitors prevented nucleoside transport. Incubation of K562 cells with SB203580, SB203580-iodo, or SB202474, an analogue of SB203580 that does not
Min, Huang, Yanhong, Wang, Matthew, Collins, Jing Jin, Gu, Beverly S, Mitchell, Lee M, Graves   +5 more
openaire   +2 more sources

Contrast bath-induced neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway

Heliyon, 2019
We investigated the differentiation and activation of p38 MAPK induced by contrast bath in drug-hypersensitive PC12m3 mutant cells. The rate of neurite outgrowth in PC12m3 cells induced by contrast bath was much higher than that induced by warming or ...
Hirotoshio Motoda, Fukumi Hiragami, Kenji Kawamura, Shigeki Inoue, Yutaka Gomita, Yoshio Kano   +5 more
doaj   +1 more source

Modification of collagen by 3-deoxyglucosone alters wound healing through differential regulation of p38 MAP kinase. [PDF]

PLoS ONE, 2011
BACKGROUND: Wound healing is a highly dynamic process that requires signaling from the extracellular matrix to the fibroblasts for migration and proliferation, and closure of the wound. This rate of wound closure is impaired in diabetes, which may be due
Danielle T Loughlin, Carol M Artlett
doaj   +1 more source

Rickettsial pathogen inhibits tick cell death through tryptophan metabolite mediated activation of p38 MAP kinase

iScience, 2023
Summary: Anaplasma phagocytophilum modulates various cell signaling pathways in mammalian cells for its survival. In this study, we report that A. phagocytophilum modulates tick tryptophan pathway to activate arthropod p38 MAP kinase for the survival of ...
Prachi Namjoshi, Mustapha Dahmani, Hameeda Sultana, Girish Neelakanta   +3 more
doaj   +1 more source

A novel cardioprotective p38-MAPK/mTOR pathway [PDF]

Experimental Cell Research, 2011
Despite intensive study, the mechanisms regulating activation of mTOR and the consequences of that activation in the ischemic heart remain unclear. This is particularly true for the setting of ischemia/reperfusion (I/R) injury. In a mouse model of I/R injury, we observed robust mTOR activation, and its inhibition by rapamycin increased injury ...
Gonzalo, Hernández, Hind, Lal, Miguel, Fidalgo, Ana, Guerrero, Juan, Zalvide, Thomas, Force, Celia M, Pombo   +6 more
openaire   +2 more sources

The relationship mammalian p38 with human health and its homolog Hog1 in response to environmental stresses in Saccharomyces cerevisiae

Frontiers in Cell and Developmental Biology
The mammalian p38 MAPK pathway plays a vital role in transducing extracellular environmental stresses into numerous intracellular biological processes.
Gang Du, Kaifang Zheng, Cunying Sun, Mingyue Sun, Jie Pan, Dan Meng, Wenqiang Guan, Hui Zhao   +7 more
doaj   +1 more source