Results 11 to 20 of about 119,547 (161)
SnapShot: p38 MAPK Substrates [PDF]
Cell, 2013 p38α mitogen-activated protein kinase (MAPK14) phosphorylates many downstream substrates, which allows this pathway to regulate a wide variety of cellular processes, including growth, proliferation, or differentiation. All p38α-mediated phosphorylations have been reported to occur on Ser or Thr residues, which are usually followed by a Pro residue ...
Natalia Trempolec +2 more
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p38 MAPK in Development and Cancer [PDF]
Cell Cycle, 2006 p38 is a MAPK that has been shown to induce a wide variety of biological effects in cell culture in response to a wide range of stimuli. These effects are dependent not only on the stimuli, but also on the cellular context, resulting in a bewildering array of possibilities.
Cynthia, Bradham, David R, McClay
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p38 MAPK Signaling in Osteoblast Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2016 The skeleton is a highly dynamic tissue whose structure relies on the balance between bone deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast functions, is controlled by multiple factors that can be modulated post-translationally.
Rodríguez Carballo, Edgardo +2 more
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Increased activation of p38 MAPK in COPD [PDF]
European Respiratory Journal, 2007 Inflammation, oxidative stress and apoptosis, which are involved in chronic obstructive pulmonary disease (COPD) pathogenesis, may activate the p38 subgroup of mitogen-activated protein kinases (MAPKs). Therefore, the aim of the present study was to evaluate the expression of the phosphorylated, active form of p38 MAPK (phospho-p38) in the lungs of ...
RENDA T +12 more
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The Regulation of Th1 Responses by the p38 MAPK [PDF]
The Journal of Immunology, 2010 Abstract IL-12 is a dimeric cytokine that is produced primarily by APCs. In this study we examined the role that the p38 MAPKs (MAPK/p38) play in regulating IL-12 production. We show that inhibition of p38 dramatically increased IL-12 production upon stimulation, while decreasing TNF-α.
Ziyan, Yang +3 more
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Aging, 2015 Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as "low-risk" and "high-risk" syndromes on the basis of their risk of progression to acute leukemia.
Gañán-Gómez, I. (Irene) +2 more
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p38 MAPK reins in right ventricular growth [PDF]
Journal of Clinical Investigation, 2020 The right ventricle (RV) is involved in systemic circulation in the fetal mammalian heart but quickly transitions to being solely responsible for pulmonary circulation after birth when the left ventricle (LV) becomes the systemic ventricle. To handle the increased workload, LV growth greatly outpaces that of the RV during postnatal stages. However, the
Tongbin Wu, Ju Chen
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Cell, 2013 Mitogen-activated protein kinase (MAPK) pathways are important regulators of cellular responses to many extracellular stimuli. Typically, eukaryotic cells have several parallel MAPK pathways, which allow the integration of signals from different stimuli.
Natalia Trempolec +2 more
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Kidney & Blood Pressure Research, 2018 Background/Aims: Multiple organ failure (MOF) is a primary threat to the survival of patients with systemic inflammation. Blood purification is employed in the treatment of MOF, as an artificial kidney or artificial liver.
Lan Ling +6 more
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EMBO Molecular Medicine, 2013 The p38 MAPK pathway is an important regulator of many cellular responses. It is well established that p38 MAPK signalling negatively regulates epithelial cell transformation, but enhanced p38 MAPK activity has been also correlated with bad clinical ...
Lorena Pereira +4 more
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