Results 11 to 20 of about 229,819 (298)
A role for p38 MAPK in the regulation of ciliary motion in a eukaryote [PDF]
BMC Cell Biology, 2011 Background Motile cilia are essential to the survival and reproduction of many eukaryotes; they are responsible for powering swimming of protists and small multicellular organisms and drive fluids across respiratory and reproductive surfaces in mammals ...
Emery Aidan M +3 more
doaj +2 more sources
The Regulation of Th1 Responses by the p38 MAPK [PDF]
The Journal of Immunology, 2010 Abstract IL-12 is a dimeric cytokine that is produced primarily by APCs. In this study we examined the role that the p38 MAPKs (MAPK/p38) play in regulating IL-12 production. We show that inhibition of p38 dramatically increased IL-12 production upon stimulation, while decreasing TNF-α.
Ziyan, Yang +3 more
openaire +3 more sources
American Journal of Physiology-Endocrinology and Metabolism, 2011 The adaptor protein APPL1 mediates the stimulatory effect of adiponectin on p38 mitogen-activated protein kinase (MAPK) signaling, yet the underlying mechanism remains unclear. Here we show that, in C2C12 cells, overexpression or suppression of APPL1 enhanced or suppressed, respectively, adiponectin-stimulated p38 MAPK upstream kinase cascade ...
Xiaoban, Xin +4 more
openaire +4 more sources
p38 MAPK regulates COPII recruitment
Biochemical and Biophysical Research Communications, 2007 Here, we investigate regulation of coat protein complex II (COPII) recruitment onto ER export sites in permeabilized cells. In cytosols from nocodazole treated HeLa cells we find COPII loading is inhibited. The stress kinase p38 MAPK is activated in these cytosols and COPII loading can be rescued by depletion of p38 MAPK alpha or by the p38 MAPK ...
Wang, Lijun, Lucocq, John M.
openaire +4 more sources
Nuclear Localization of p38 MAPK in Response to DNA Damage
International Journal of Biological Sciences, 2009 p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints.
C. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon
doaj +1 more source
SnapShot: p38 MAPK Substrates [PDF]
Cell, 2013 p38α mitogen-activated protein kinase (MAPK14) phosphorylates many downstream substrates, which allows this pathway to regulate a wide variety of cellular processes, including growth, proliferation, or differentiation. All p38α-mediated phosphorylations have been reported to occur on Ser or Thr residues, which are usually followed by a Pro residue ...
Natalia Trempolec +2 more
openaire +2 more sources
p38 MAPK in Development and Cancer [PDF]
Cell Cycle, 2006 p38 is a MAPK that has been shown to induce a wide variety of biological effects in cell culture in response to a wide range of stimuli. These effects are dependent not only on the stimuli, but also on the cellular context, resulting in a bewildering array of possibilities.
Cynthia, Bradham, David R, McClay
openaire +2 more sources
p38 MAPK Signaling in Osteoblast Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2016 The skeleton is a highly dynamic tissue whose structure relies on the balance between bone deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast functions, is controlled by multiple factors that can be modulated post-translationally.
Rodríguez Carballo, Edgardo +2 more
openaire +5 more sources
Increased activation of p38 MAPK in COPD [PDF]
European Respiratory Journal, 2007 Inflammation, oxidative stress and apoptosis, which are involved in chronic obstructive pulmonary disease (COPD) pathogenesis, may activate the p38 subgroup of mitogen-activated protein kinases (MAPKs). Therefore, the aim of the present study was to evaluate the expression of the phosphorylated, active form of p38 MAPK (phospho-p38) in the lungs of ...
RENDA T +12 more
openaire +6 more sources
Aging, 2015 Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as "low-risk" and "high-risk" syndromes on the basis of their risk of progression to acute leukemia.
Gañán-Gómez, I. (Irene) +2 more
openaire +3 more sources