Results 81 to 90 of about 229,819 (298)
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
PLoS ONE, 2019 Activation of p38 mitogen-activated protein kinase (MAPK) is associated with tissue fibrosis, and inhibition of p38 MAPK can attenuate the progression of fibrosis.
Jeonghwan Lee +5 more
doaj +1 more source
Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia
Advanced Science, EarlyView.The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian +12 more
wiley +1 more source
Journal of the Egyptian Women’s Dermatologic Society, 2020 Background Although the exact pathogenic mechanisms leading to blister formation in pemphigus vulgaris (PV) have not been fully elucidated, intracellular signaling following antibody binding has been found to be necessary for inducing cell-cell ...
Shereen A Sobeih +4 more
doaj +1 more source
1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients. [PDF]
PLoS ONE, 2015 Reduced neutrophil apoptosis plays an important role in the pathogenesis of acute exacerbation chronic obstructive pulmonary disease (AECOPD). The p38 mitogen-activated protein kinase (MAPK) signaling pathway is involved in neutrophil apoptosis.
Haihua Yang +13 more
doaj +1 more source
The expression and activation of p38 MAPK does not change following LAD ligation.
, 2013 Western blots with anti-phospho-p38 MAPK antibody and anti-p38 MAPK antibody demonstrate that both p38 MAPK and phospho-p38 MAPK are barely detectable in aortic smooth muscle in control and rats following LAD ligation (CHF, CHF+losartan).
Frank V. Brozovich (373357) +1 more
core +1 more source
Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis
Advanced Science, EarlyView.Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang +9 more
wiley +1 more source
AKT-independent activation of p38 MAP kinase promotes vascular calcification
Redox Biology, 2018 Vascular calcification is prevalent in patients with atherosclerosis, and oxidative stress promotes pathogenesis of atherosclerosis. We have previously reported that activation of AKT by oxidative stress induces vascular calcification.
Youfeng Yang +6 more
doaj +1 more source
Changes in hepatic p38 MAPK activation after hemorrhage.
, 2013 The activation of p38 MAPK was assessed by Western blotting analysis. p38 MAPK phosphorylation levels, shown on the vertical axis in B, were determined after normalization using the density ratio of the phosphorylated p38 MAPK band (p-p38 MAPK in A ...
Noriyuki Tanaka (169920) +2 more
core +1 more source
Advanced Science, EarlyView.DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang +8 more
wiley +1 more source