Results 101 to 110 of about 229,819 (298)

Inhibition of p38 MAPK after repetitive mTBI ameliorates immune signaling and functional deficits

Acta Neuropathologica Communications
Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can lead to long-term neurological impairments. Following mechanical impact, increasing evidence suggests that the brain undergoes an inflammatory cascade ...
Chenxing Li, Martin N. Griffin, Sydney E. Triplett, Anna E. Silverio, Elizabeth Pettit, Alivia M. Rohrer, Jacob P. Callaway, Pranavvarma V. Munagapati, Paul F. Saah, Paul I. Sanz, Felix G. Rivera Moctezuma, Abigail Holberton, Angela Gomez, Erin M. Buckley, Levi B. Wood   +14 more
doaj   +1 more source

Neuronal p38 MAPK Signaling Contributes to Cisplatin-Induced Peripheral Neuropathy

Antioxidants
This study investigates the role of p38 mitogen-activated protein kinase (MAPK) activation in dorsal root ganglion (DRG) neurons in the development and progression of chemotherapy-induced peripheral neuropathy (CIPN).
Yugal Goel, Donovan A. Argueta, Kristen Peterson, Naomi Lomeli, Daniela A. Bota, Kalpna Gupta   +5 more
doaj   +1 more source

Evaluation of p38 MAPK signaling pathway by western blotting.

, 2015
(A) rhGM-CSF induced activation of the p38 MAPK signaling pathway. HCECs were treated with different concentrations of rhGM-CSF (0.1, 1.0, and 10.0 μg/ml) for 60 min.
Chang Rae Rho (796453), Mi-young Park (796454), Seungbum Kang (480336)   +2 more
core   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

NKCC1 Regulates mTORC1 and p38-MAPK

, 2020
The Mammalian Target Of Rapamycin Complex1 (mTORC1) is a key regulator of cell growth and survival. It is activated by growth factors and by essential amino acids such as Leu. Influx of Leu into cells is mediated by the Leu transporter LAT1-4F2hc (LAT1).
Demian, Wael
core  

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

The distribution of p38(MAPK) in the sensorimotor cortex of a mouse model of Alzheimer’s disease [PDF]

, 2011
The p38 mitogen-activated protein kinase [p38(MAPK)] mediates responses to extracellular stressors. An increase in the phosphorylated form of p38(MAPK) [p-p38(MAPK)] has been associated with early events in Alzheimer disease (AD).
ZHAO, TUO
core  

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

International Journal of Endocrinology, 2016
Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
Li Peng, Jie Li, Yixing Xu, Yangtian Wang, Hong Du, Jiaqing Shao, Zhimin Liu   +6 more
doaj   +1 more source

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source