Results 121 to 130 of about 119,547 (161)
Involvement of p38 MAPK in Synaptic Function and Dysfunction [PDF]
International Journal of Molecular Sciences, 2020 Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD). However, p38 MAPK is classically known as a responsive element to stress stimuli, including neuroinflammation.
Ottavio Arancio +2 more
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Crosstalk between p38 MAPK and GR Signaling
International Journal of Molecular Sciences, 2022 The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation.
Ingvild Mikkola +2 more
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The Role of p38 MAPK in the Development of Diabetic Cardiomyopathy [PDF]
International Journal of Molecular Sciences, 2016 Diabetic cardiomyopathy (DCM) is a major complication of diabetes that contributes to an increase in mortality. A number of mechanisms potentially explain the development of DCM including oxidative stress, inflammation and extracellular fibrosis. Mitogen-activated protein kinase (MAPK)-mediated signaling pathways are common among these pathogenic ...
Shudong Wang, Wang Shudong
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Inactivation of p38 MAPK during liver regeneration [PDF]
International Journal of Biochemistry and Cell Biology, 2011 There is increasing evidence that p38 MAPK, which is classified as a stress-activated kinase, also participates in cell cycle regulation, functioning as a suppressor of cell proliferation and tumorigenesis. We conducted a study of p38 MAPK phosphorylation during liver regeneration in mice to determine whether p38 MAPK activation or inactivation may ...
Brian J Hayes +2 more
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Impact of curcumin on p38 MAPK: therapeutic implications
Inflammopharmacology, 2023Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including nuclear factor kappa B (NF-KB), reactive oxygen species (ROS), Wingless/Integrated (Wnt), Janus kinase-signal ...
Hedieh Sadat Shamsnia +9 more
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Mechanisms and functions of p38 MAPK signalling
Biochemical Journal, 2010The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects. The diversity and specificity in cellular outcomes is achieved with an apparently simple linear architecture of the pathway, consisting of a ...
Cuadrado, Ana, Nebreda, Angel R.
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p38 MAPK regulates COPII recruitment
Biochemical and Biophysical Research Communications, 2007Here, we investigate regulation of coat protein complex II (COPII) recruitment onto ER export sites in permeabilized cells. In cytosols from nocodazole treated HeLa cells we find COPII loading is inhibited. The stress kinase p38 MAPK is activated in these cytosols and COPII loading can be rescued by depletion of p38 MAPK alpha or by the p38 MAPK ...
Wang, Lijun, Lucocq, John M.
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Roles of p38 MAPKs in invasion and metastasis
Biochemical Society Transactions, 2012Cells from primary tumours need to go through several steps to become fully metastatic. During this process, cancer cells acquire the ability to invade, migrate across the surrounding tissue, enter into the circulation and colonize distant organs. In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated ...
Barrantes, Ivan Del Barco +1 more
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Pyridazine based inhibitors of p38 MAPK
Bioorganic & Medicinal Chemistry Letters, 2002Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38MAPK. The most active isomers were those possessing an aryl group alpha and a heteroaryl group beta relative to the nitrogen atom in the 2-position of the central pyridazine.
Charles J, McIntyre +7 more
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