Results 131 to 140 of about 119,547 (161)
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p38 MAPK signalling cascades in inflammatory disease
Trends in Molecular Medicine, 1999Inflammatory mediators released during acute and chronic diseases activate multiple intracellular signalling cascades including the mitogen-activated protein kinase (MAPK) signal transduction pathway, which plays a significant role in the recruitment of leukocytes to sites of inflammation.
E, Herlaar, Z, Brown
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2007
There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
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There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
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Azastilbenes: a cut-off to p38 MAPK inhibitors
Organic & Biomolecular Chemistry, 2013Inhibitors with vicinal 4-fluorophenyl/4-pyridine rings on a five- or six-membered heterocyclic ring are known to inhibit the p38 mitogen-activated protein kinase (MAPK), which is a potential target for rheumatoid arthritis and several different types of cancer.
Jia-Fei, Poon +3 more
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p38 MAPK inhibitors in dermatology
Expert Review of Dermatology, 2007p38 mitogen-activated protein kinase (MAPK) is involved in regulating cell growth, cell differentiation, cell proliferation, cell apoptosis and response to inflammation and stress. Four mammalian p38 MAPK isoforms, p38 MAPKα, p38 MAPKβ, p38 MAPKγ (ERK6/SAPK3) and p38 MAPKδ (SAPK4), have been identified.
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p38 MAPK: A Potential Target of Chronic Pain
Current Medicinal Chemistry, 2014p38 mitogen-activated protein kinases (p38 MAPK, p38) consist of 4 subunits: p38α, p38β, p38γ and p38δ. They play a well-recognized role in regulating intracellular signaling transduction in mammalian cells. p38 MAPK induces a variety of intracellular responses associated with neuropathic pain and other chronic pain.
X, Lin, M, Wang, J, Zhang, R, Xu
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Regulation of GDF-8 signaling by the p38 MAPK
Cellular Signalling, 2005Growth differentiation factor-8 (GDF-8), a member of the TGF-beta superfamily, is a negative regulator of skeletal muscle growth, which functions through activation of the Smad proteins. We found that GDF-8 can activate the p38 mitogen-activated protein kinase (MAPK) through the TGF-beta-activated kinase 1 (TAK1), and this appeared to be independent of
Bevin, Philip, Zhijian, Lu, Yijie, Gao
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p38 MAPK Signaling in Oral-related Diseases
Journal of Dental Research, 2007Multiple dental diseases are characterized by chronic inflammation, due to the production of cytokines, chemokines, and prostanoids by immune and non-immune cells. Membrane-bound receptors provide a link between the extracellular environment and the initiation of intracellular signaling events that activate common signaling components, including p38 ...
C S, Patil, K L, Kirkwood
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Novel strategies for inhibition of the p38 MAPK pathway
Trends in Pharmacological Sciences, 2007The p38 subgroup of the mitogen-activated protein kinase superfamily has four isoforms: p38alpha, p38beta, p38delta and p38gamma. Whereas p38alpha is involved in inflammation, proliferation, differentiation and apoptosis, the biological functions of p38beta, p38delta and p38gamma are not understood completely.
Jiyan, Zhang, Beifen, Shen, Anning, Lin
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IGF2BP1: a novel binding protein of p38 MAPK
Molecular and Cellular Biochemistry, 2017Signal transduction pathways control various biological processes in cells leading to distinct cellular functions. Protein-protein interactions and post-translational modifications are the physiological events that occur in signaling pathway. p38 MAPK are known to be involved in regulating wide range of cellular processes by interacting and activating ...
Jacob, Rini, Moorthy, Anbalagan
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The role of MAPK p44/42 and MAPK p38 in associative olfactory
2005In dieser Arbeit wurde die Rolle der MAPK-Kaskade im assoziativen appetitiven Lernen sowie im nicht-assoziativen Lernen untersucht. Unter Verwendung von hochspezifischen Antikörpern gegen MAPK p44/42, phospho-MAPK p44/42, MAPK p38 und phospho-MAPK p38 war es möglich, diese Proteine zu quantifizieren.
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