Results 141 to 150 of about 229,819 (298)

Hyperactive KIF5A in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos, James N. Sleigh   +1 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Therapeutic capabilities of naturally-derived p38 MAPK inhibitors for protecting the cerebrovascular system in severe SARS‑CoV‑2 infection

Medicine in Drug Discovery
In COVID‑19, hyper‑inflammatory responses are associated with increased p38 MAPK activity, which may arise from the loss of ACE2 following SARS‑CoV‑2 infection.
Mohammad Sheibani, Vasiliki Epameinondas Georgakopoulou, Maryam Mohammadi, Elaheh Abdollahi, Zahra Zakeri Khatir, Mehdi Valipour   +5 more
doaj   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Critical Role of p38α MAPK Subclass in the Development of Pain Hypersensitivity After Hind Paw Incision

Journal of Pain Research
Daiki Ishikawa,1 Shunsuke Yamakita,1 Kentaro Oh-Hashi,2– 4 Fumimasa Amaya1 1Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University,
Ishikawa D, Yamakita S, Oh-Hashi K, Amaya F   +3 more
doaj  

Effect of morphine on p38 MAPK and MEKK3/6 activation.

, 2013
WT, TLR9 KO, and µOR KO microglial cells were treated with morphine at 5 and 10 µM for 24 hr. (A) Total and phosphorylated p38 MAPK (p-p38 MAPK) levels were determined by Western blot.
Yi Zhang (9093), Yi Li (1144), Hui Li (32376), Xiumei Zhang (352357), Gregory Hanley (352356), Gene LeSage (352358), Deling Yin (352359), Lin Chen (54305), Zuoxiang Xiao (352355), Ying Peng (26452), Junying Miao (352353), Lei He (143930), Yulin Jiang (352354)   +12 more
core   +1 more source

Anti‐Inflammatory Effects of Punicic Acid and Its Molecular Mechanisms in RAW264.7 Cells and Zebrafish

Food Safety and Health, EarlyView.
Punicic acid (PA) was enriched and purified from PSO by molecular distillation with significant anti‐inflammatory activity to RAW264.7 cells, as well as to zebrafish. Anti‐inflammatory mechanism involved regulating NF‐κB and MAPK signaling pathways. ABSTRACT Punicic acid (PA) is the main fatty acid in pomegranate seeds, which shows multiple biological ...
Mengqi Zhang, Caiyun Feng, Mengyao Zhu, Xu Guo, Yingying Chen, Wenwen Hu, Fei Dong, Jinyue Sun, Chao Liu   +8 more
wiley   +1 more source

P38 MAPK expression and activation predicts failure of response to CHOP in patients with Diffuse Large B-Cell Lymphoma. [PDF]

, 2015
The p38 MAPK is constitutively activated in B-NHL cell lines and regulates chemoresistance. Accordingly, we hypothesized that activated p38 MAPK may be associated with the in vivo unresponsiveness to chemotherapy in B-NHL patients.Tissue microarrays ...
Chalapud, J Ramón, Martinez-Maza, Otoniel, Huerta-Yepez, Sara, Mayani, Héctor, Pelayo, Rosana, Bonavida, Benjamin, Martinez-Paniagua, Melisa, Vega, Mario I, Vega, Gabriel G, Avilés-Salas, Alejandro, Hernandez-Pando, Rogelio   +10 more
core  

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source