Results 21 to 30 of about 164,331 (306)
Recruitment of JNK to JIP1 and JNK-dependent JIP1 Phosphorylation Regulates JNK Module Dynamics and Activation [PDF]
Journal of Biological Chemistry, 2003 JIP1 is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase-dependent JNK module. Results of earlier work led us to propose a model for JIP1-JNK complex regulation that predicts that under basal conditions, JIP1 maintains DLK in a monomeric, unphosphorylated, and catalytically inactive state.
Deepak, Nihalani +2 more
openaire +2 more sources
JNK and cardiometabolic dysfunction [PDF]
Bioscience Reports, 2019 Abstract Cardiometabolic syndrome (CMS) describes the cluster of metabolic and cardiovascular diseases that are generally characterized by impaired glucose tolerance, intra-abdominal adiposity, dyslipidemia, and hypertension. CMS currently affects more than 25% of the world’s population and the rates of diseases are rapidly rising. These
Siobhan M. Craige +4 more
openaire +4 more sources
JNK signaling in apoptosis [PDF]
Oncogene, 2008 Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and ...
D N, Dhanasekaran, E P, Reddy
openaire +2 more sources
The functional contrariety of JNK [PDF]
Molecular Carcinogenesis, 2007 AbstractThe JNK proteins are activated by multiple and diverse stimuli, leading to varied and seemingly contradictory cellular responses. In particular, JNKs have been reported to have a role in the induction of apoptosis, but have also been implicated in enhancing cell survival and proliferation. Thus the JNK proteins seem to represent an archetype of
Ann M, Bode, Zigang, Dong
openaire +2 more sources
The expression of MAPK signaling pathways in conjunctivochalasis [PDF]
International Journal of Ophthalmology, 2019 This study investigated the potential role of MAPK signaling pathways in conjunctivochalasis (CCH). Twenty loose conjunctival biopsy samples from 20 CCH and 15 conjunctival biopsy samples from 15 normal controls (CON) were collected.
Yuan-Ling Jia +4 more
doaj +1 more source
Spz/Toll-6 signal guides organotropic metastasis in Drosophila
Disease Models & Mechanisms, 2019 Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers, providing a powerful model to study developmental and cancer biology.
Ketu Mishra-Gorur +5 more
doaj +1 more source
Impact of JNK and Its Substrates on Dendritic Spine Morphology
Cells, 2020 The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal regulatory proteins.
Emilia Komulainen +6 more
doaj +1 more source
Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years.
Yoo Jin Na +5 more
doaj +1 more source
JNK signalling in cancer: In need of new, smarter therapeutic targets [PDF]
, 2014 Copyright © 2013 The British Pharmacological Society. This is the accepted version of the following article: Bubici, C. and Papa, S. (2014), JNK signalling in cancer: in need of new, smarter therapeutic targets.
Concetta Bubici +3 more
core +1 more source
Biomolecules, 2019 Lead (Pb) is a toxic heavy metal pollutant with adverse effects on the liver and other body organs. Curcumin (CUR) is the principal curcuminoid of turmeric and possesses strong antioxidant and anti-inflammatory activities.
Ahlam Alhusaini +5 more
doaj +1 more source