Results 21 to 30 of about 254,157 (265)

High water intake induces primary cilium elongation in renal tubular cells [PDF]

Kidney Research and Clinical Practice
Background The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and a blockage of the shortening disturbs the ability of ...
Min Jung Kong, Sang Jun Han, Sung Young Seu, Ki-Hwan Han, Joshua H. Lipschutz, Kwon Moo Park   +5 more
doaj   +1 more source

MAPK-ERK Pathway

International Journal of Molecular Sciences, 2023
The name extracellular signal-regulated kinase (ERK) was first used for a cell cycle regulating Ser/Thr protein kinase cloned in mammalian cells [...]
openaire   +2 more sources

The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis

Reproductive Biology and Endocrinology, 2022
Abstract Background Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase signaling that is secondary to a genetic problem contributes to both ovulatory dysfunction and ...
Gurhan Guney, Mine Islimye Taşkın, Nazli Sener, Ezgi Tolu, Yavuz Dodurga, Levent Elmas, Orkun Cetin, Cengiz Sarigul   +7 more
openaire   +5 more sources

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Rosavin exerts an antitumor role and inactivates the MAPK/ERK pathway in small-cell lung carcinoma in vitro

Acta Pharmaceutica, 2023
This study attempts to explore the function and mechanism of action of rosavin in small-cell lung cancer (SCLC) in vitro. The viability and clone formation of SCLC cells were assessed using cell counting kit-8 and colony formation assays, respectively ...
Liu Rui, Jiang Cuihong, Zhao Zhizheng, Lv Yutong, Wang Gaoxing   +4 more
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Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells

Acta Pharmaceutica, 2021
Renal cell carcinoma (RCC) is generally acknowledged as the most resistant primary malignancy unresponsive to conventional radiotherapy and chemotherapy treatments.
Huang Shuaishuai, Tuergong Gulimire, Zhu Hangjie, Wang Xue, Weng Guobin, Ren Yu   +5 more
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The Role of Autophagy in M2 Polarization of Macrophages Induced by Micro/Nano Topography

International Journal of Nanomedicine, 2020
Jing Luo,1,2,* Yide He,1,* Fanhui Meng,1,3,* Ning Yan,1 Yumei Zhang,1 Wen Song1 1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of ...
Luo J, He Y, Meng F, Yan N, Zhang Y, Song W   +5 more
doaj  

PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer

Cancer Biology & Therapy, 2022
The tumor recurrence and drug resistance of hepatocellular carcinoma (HCC) threatened patients a lot. The mechanism should be further explored. The information of expression status and survival were available in public databases.
Hanpu Zhang, Chenyuan Li, Shichong Liao, Yi Tu, Shengrong Sun, Feng Yao, Zhiyu Li, Zhong Wang   +7 more
doaj   +1 more source

Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/BRAF/TAK1/ERK/ETV4 signaling

Cancer Biology & Medicine, 2022
Objective: PD-L1 and PD-L2 expression levels determine immune evasion and the therapeutic efficacy of immune checkpoint blockade. The factors that drive inducible PD-L1 expression have been extensively studied, but mechanisms that result in constitutive ...
Panpan Ma, Xinxin Jin, Zhiwei Fan, Zhou Wang, Suhui Yue, Changyue Wu, Shiyin Chen, Yuanyuan Wu, Miaomiao Chen, Donghua Gu, Siliang Zhang, Renfang Mao, Yihui Fan   +12 more
doaj   +1 more source