Results 11 to 20 of about 331,296 (302)
The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis [PDF]
Reproductive Biology and Endocrinology, 2022 Abstract Background Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase signaling that is secondary to a genetic problem contributes to both ovulatory dysfunction and ...
Gurhan Guney +7 more
openaire +6 more sources
ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy
Clinical Cancer Research, 2018 Abstract Purpose: MAPK pathway inhibitors targeting BRAF and MEK have shown clinical efficacy in patients with RAF- and/or RAS-mutated tumors. However, acquired resistance to these agents has been an impediment to improved long-term survival in the clinic.
Bijay S, Jaiswal +9 more
openaire +3 more sources
Journal of Signal Transduction, 2011 Acute or chronic kidney injury results from various insults and pathological conditions, and is accompanied by activation of compensatory repair mechanisms. Both insults and repair mechanisms are initiated by circulating factors, whose cellular effects are mediated by activation selective signal transduction pathways.
Feliers, Denis +1 more
openaire +2 more sources
Diabetes, 2014 Increasing energy expenditure is an attractive approach to fighting the worldwide epidemic in obesity and type 2 diabetes. Exercise is an important component of good health and represents the first line of therapy for humans with a variety of metabolic disorders: obesity, diabetes, and nonalcoholic hepatic steatosis. Recent data has shown that exercise,
Wu, Jun, Spiegelman, Bruce
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, 2021 Rational design of a drug delivery system with enhanced therapeutic potency is critical for efficient tumor chemotherapy. Many protein-based drug delivery platforms have been designed to deliver drugs to target sites and improve the therapeutic efficacy.
Xun Li +9 more
core +1 more source
ERK signal duration decoding by mRNA dynamics [PDF]
, 2018 Der RAF-MEK-ERK-Signalweg steuert grundlegende, oftmals entgegengesetzte zelluläre Prozesse wie die Proliferation und Apoptose von Zellen. Die Dauer des vermittelten Signals wurde als entscheidener Faktor für die Steuerung dieser Prozesse identifiziert ...
Uhlitz, Florian Sören
core +1 more source
The C-terminal truncated splicing variant of NK1R negatively modulates substance P-stimulated NK1R signaling. [PDF]
FEBS Open BioThe neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Nguyen LP +8 more
europepmc +2 more sources
Journal of Cell Biology, 2010 In this issue, a study by Groehler and Lannigan (2010. J. Cell Biol. doi:10.1083/jcb.201002124) sheds light on the regulation of proliferating cell nuclear antigen (PCNA) turnover and how it is counteracted by the small chromatin-bound kinase ERK8 (extracellular signal-regulated kinase 8). Importantly, inactivation of ERK8 results in genome instability
Nguyen, Hai Dang, Bielinsky, Anja-Katrin
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Redox Report, 2022 Objective Genistein is a recognized isoflavone present in soybeans with antioxidant, anti-inflammatory, antiangiogenic and antitumor activities. This study aimed to test ability of genistein in modulating versican/platelet derived growth factor (PDGF ...
Yousra M. El-Far +4 more
doaj +1 more source
Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]
, 2009 This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Gormand, A +27 more
core +1 more source