Results 41 to 50 of about 331,296 (302)
eLife, 2019 Predicting ancestral sequences of protein kinases reveals the molecular details that underlie different modes of activation.
Suk ho Hong, Neel H Shah
doaj +1 more source
Lighting Up ERK Activity [PDF]
Developmental Cell, 2017 Activation of extracellular signal regulated kinase (ERK) is used by many signaling pathways to control tissue patterning in a broad range of multicellular organisms. In this issue of Developmental Cell, Johnson et al. (2017) provide an optogenetic approach to manipulate this pathway with high precision and explore its signaling code.
Ben-Zion, Shilo, Naama, Barkai
openaire +2 more sources
TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway
, 2023 Critical-size defects (CSDs) are challenging oral clinical issues that need to be solved. Adipose-derived mesenchymal stem cells (ADSCs) and gene therapy offer a new target to solve these issues.
Jian Zheng (287758) +8 more
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
An improved Erk biosensor reveals oscillatory Erk dynamics driven by mitotic erasure during early development [PDF]
, 2022 Erk signaling dynamics elicit distinct cellular responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore the role of Erk signaling dynamics in vivo, as a gradient of activated diphosphorylated Erk (P-Erk) is induced by ...
Wilcockson, Scott +4 more
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Overexpression of RASAL1 indicates poor prognosis and promotes invasion of ovarian cancer
Open Life Sciences, 2019 RAS protein activator like-1 (RASAL1) exists in numerous human tissues and has been commonly demonstrated to act as a tumor suppressor in several cancers. This study aimed to identify the functional characteristics of RASAL1 in ovarian adenocarcinoma and
Chang Rui-Xia +5 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Transforming growth factor-beta 1 enhances discharge activity of cortical neurons
Neural Regeneration ResearchTransforming growth factor-beta 1 (TGF-β1) has been extensively studied for its pleiotropic effects on central nervous system diseases. The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and
Zhihui Ren +7 more
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Aufschwung des Klausenburger Musiklebens in der ersten Hälfte des 19. Jahrhunderts
Studia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica, 2019 Cluj's music culture, emerging during the first half of the 19ᵗʰ century. The article focuses on the developing music culture of Cluj, one of the important cities in Transylvania, the easternmost province of Austria-Hungary.
Erich TÜRK
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CXCR7/p-ERK-Signaling Is a Novel Target for Therapeutic Vasculogenesis in Patients with Coronary Artery Disease. [PDF]
, 2016 Coronary artery disease (CAD) is characterized by insufficient vasculogenic response to ischemia, which is typically accompanied by dysfunction of endothelial outgrowth cells (EOCs).
Xiaoyu Zhang +15 more
core +1 more source