Results 61 to 70 of about 254,157 (265)
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
Pharmaceutical Biology, 2020 Context Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle.
Wen-qiang Cao +6 more
doaj +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Cells, 2019 The activation of hepatic stellate cells (HSCs) manifested as proliferation and migration is the pivotal event involved in liver fibrogenesis. The vimentin network, an intermediate filament (IF) system, is one of the critical cascades by which the cell ...
Pei-Wen Wang +5 more
doaj +1 more source
ERK plays the baddie (again) [PDF]
Cancer Biology & Therapy, 2013 It has been known for many years that elevated signaling by the ERK1/2 pathway is frequently associated with the growth and survival of many tumor cell types under a variety of normal and stressful conditions, including the response of cells to other cancer interventional therapeutic strategies e.g., references 1–4.
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Ancestral reconstruction reveals mechanisms of ERK regulatory evolution
eLife, 2019 Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. Previously we used ancestral reconstruction to determine how CMGC group kinase specificity evolved (Howard et al., 2014).
Dajun Sang +8 more
doaj +1 more source
Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review
Advanced Materials, EarlyView.Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase +6 more
wiley +1 more source
Hair growth potential of Salvia plebeia extract and its associated mechanisms
Pharmaceutical Biology, 2020 Context Although Salvia plebeia (SP) R. Brown (Labiatae) is known to possess various biological activities, the effects of SP on hair growth have not been elucidated.
Guang-Ri Jin +4 more
doaj +1 more source
Advanced Materials Interfaces, EarlyView.Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung +6 more
wiley +1 more source