Results 51 to 60 of about 331,296 (302)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Mass Driver Design Traveling Earth to the Moon

IEEE Access, 2019
In this article, the flight of a mass driver was designed for launch from the Earth with Electro Magnetic Space Launching System (EMSLS). Then the orbit exit from the Earth at 185 km and orbit entry the Moon at 100kmwere examined with respect to change ...
Erk Inger
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription

Cell Structure and Function
Extracellular signal-regulated kinase (ERK) regulates multiple cellular functions through distinct activation patterns. Genetically encoded fluorescent probes are instrumental in dissecting the ERK activity dynamics in living cells.
Zhang Weisheng, Jun Nakayama, Yukino Inomata, Shigeki Higashiyama, Toru Hiratsuka   +4 more
doaj   +1 more source

Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signalling

Pharmaceutical Biology, 2019
Context: Oxymatrine (OMT) has various pharmacological effects, including immune reaction regulation, anti-inflammation and anti-hypersensitive reaction.
Zhiqiang Zhang, Qingfeng Liu, Hui Zang, Qingliang Shao, Tian Sun   +4 more
doaj   +1 more source

Exercise and Nano-curcumin supplementation mediates cross-talk between MAPK/ERK signaling in the regulation of inflammatory disease [PDF]

Journal of Exercise & Organ Cross Talk
Impaired cell internal settings and excessive proliferation causes the occurrence of diverse ranges of syndrom and diseases. The pathological stress underlying these conditions triggers persistent flux through multiple intracellular signaling pathways ...
Zahra Vafaeimastanabad, Nader Hamedchaman, Masoumeh Hosseini, Amir Maleki   +3 more
doaj   +1 more source

ERKs Weigh in on Ribosome Mass [PDF]

Molecular Cell, 2001
In this issue of Molecular Cell, Stefanovsky et al. demonstrate that the activation of the ERK1/2 MAP kinases by growth factors leads to induction of ribosomal gene transcription, through a mechanism dependent on phosphorylation of the upstream binding factor (UBF). This provides a connection between growth factor signaling and increased translation.
Gallagher, Ewen D., Cobb, Melanie H.
openaire   +2 more sources

Developmental ERK Signaling Goes Digital. [PDF]

, 2017
Reporting in Developmental Cell, de la Cova et al. (2017) present a biosensor to measure ERK activity dynamics in C. elegans larvae. They find that fate decision signaling involves frequency-modulated, digital ERK activity pulses.
Coralie Dessauges, Olivier Pertz, Dessauges, Coralie, Pertz, Olivier, Pertz O, Dessauges C   +5 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source