Results 71 to 80 of about 331,296 (302)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Basal phosphorylation level of ERK.
, 2015 Cell extracts were subjected to western blotting using anti-phosphorylated ERK (P-ERK) and anti-ERK (ERK) antibodies. (a) Basal phosphorylation level of ERK in HeLa cells seeded at 1.5 x 104 and 0.5 x 104 cells/cm2.
Mitsuhiro Morita (798863) +4 more
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Bidirectional Signals Transduced by Dapk–Erk Interaction Promote the Apoptotic Effect of Dapk
, 2008 Death-associated protein kinase (DAPK) is a death domain- containing serine/threonine kinase, and participates in various apoptotic paradigms. Here, we identify the extracellular signal-regulated kinase (ERK) as a DAPK- interacting protein.
陳俊豪;王琬菁;張智芬;陳瑞華 +3 more
core
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
, 1893 ges. u. erl. von Ludwig Erk. Im Auftr. ... der Königlich Preußischen Regierung ... neubearb. u. fortges. v. Franz M.
Erk, Ludwig
core +1 more source
Pharmaceutical Biology, 2020 Context Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle.
Wen-qiang Cao +6 more
doaj +1 more source
Model predictions related to the factors affecting Erk activity.
, 2023 (A) Graphical explanation of the numerical procedure. We consider two generic curves A and B with Hill coefficients nA and nB respectively. The shape of both curves depends on the value of a parameter p that can range from 0 to 1. On the left, the curves
Clare Hudson (14564666) +6 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
, 1894 ges. u. erl. von Ludwig Erk. Im Auftr. ... der Königlich Preußischen Regierung ... neubearb. u. fortges. v. Franz M.
Erk, Ludwig
core +1 more source