Results 1 to 10 of about 87,027 (145)

Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway [PDF]

Advanced Science
The Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in the development ...
Liu X, Liu X, Liu Y, Long A, Liu W, Sun S, Lu S, Wu X, Jia X, Jose PA, Wei Q, Jiang X, Zhang H, Yang Z.   +13 more
exaly   +6 more sources

Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation [PDF]

Nature Communications
The CCKBR agonists induce neocortical long-term potentiation of excitatory synaptic transmission and enhance memory formation, while its antagonists weaken the potentiation in the amygdala and alleviate depression-like behaviors.
Jufang He, Stephen Bello, Mengfan Zhang   +2 more
exaly   +5 more sources

Low expression of CCKBR in the acinar cells is associated with insufficient starch hydrolysis in ruminants [PDF]

Communications Biology
Unlike monogastric animals, ruminants exhibit significantly lower starch digestibility in the small intestine. A better understanding of the physiological mechanisms that regulate digestion patterns in ruminants could lead to an increased use of starch ...
Zhiliang Tan, Yan Cheng, Zhang Tianqi
exaly   +5 more sources

Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway. [PDF]

Diabetes Metab J
Background Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal NHEs ...
Zhang X, Zhang Y, Shi Y, Shi D, Niu M, Liu X, Liu X, Yang Z, Wu X.   +8 more
europepmc   +4 more sources

Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development [PDF]

PLoS ONE, 2015
Cholecystokinin (CCK), a peptide hormone and one of the most abundant neuropeptides in vertebrate brain, mediates its actions via two G-protein coupled receptors, CCKAR and CCKBR, respectively active in peripheral organs and the central nervous system ...
Murat Gunel, Kaya Bilguvar, Nenad Sestan   +2 more
exaly   +5 more sources

Cholecystokinin modulates age-dependent thalamocortical neuroplasticity. [PDF]

Elife
The thalamocortical pathways exhibit neuroplasticity not only during the critical period but also in adulthood. In this study, we investigated how cholecystokinin (CCK) modulates age-dependent thalamocortical plasticity.
Li X, Feng J, Hu X, Zhou P, Chen T, Zheng X, Jendrichovsky P, Wang X, Chen M, Li H, Chen X, Zeng D, Zhang M, Xiao Z, He L, Bello ST, He J.   +16 more
europepmc   +2 more sources

Single nucleotide polymorphisms on Cholecystokinin B Receptor gene as a candidate gene for crowing in Pelung chickens. [PDF]

J Adv Vet Anim Res
Objective: This study aims to explore mutation based on single nucleotide polymorphism (SNP) in the Cholecystokinin B receptor (CCKBR) gene of Pelung chickens.
Asmara IY, Hilmia N, Garnida D.
europepmc   +2 more sources

Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species. [PDF]

J Dev Biol
The stomach has been a highly conserved organ throughout vertebrate evolution; however, there are now over 20 lineages composed of monotremes, lungfish and teleost fish displaying a secondary loss of stomach function and morphology.
Dann J, Grützner F.
europepmc   +2 more sources

Identification of gastric cancer biomarkers through in-silico analysis of microarray based datasets. [PDF]

Biochem Biophys Rep
Gastric cancer is among the most prevalent cancers worldwide including in Pakistan. Late diagnosis of gastric cancer leads to reduced survival. The present study aimed to investigate biomarkers for early diagnosis and prognosis of gastric cancer.
Akhtar A, Hameed Y, Ejaz S, Abdullah I.
europepmc   +2 more sources

Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged Alzheimer's disease mice. [PDF]

Alzheimers Res Ther
Background As one major symptom of Alzheimer’s disease (AD), anterograde amnesia describes patients with an inability in new memory formation. The crucial role of the entorhinal cortex in forming new memories has been well established, and the ...
Zhang N, Sui Y, Jendrichovsky P, Feng H, Shi H, Zhang X, Xu S, Sun W, Zhang H, Chen X, Tortorella MD, He J.   +11 more
europepmc   +2 more sources