Results 31 to 40 of about 87,027 (145)

Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice

Frontiers in Molecular Neuroscience, 2021
Rising serum estradiol triggers the surge release of gonadotropin-releasing hormone (GnRH) at late proestrus leading to ovulation. We hypothesized that proestrus evokes alterations in peptidergic signaling onto GnRH neurons inducing a differential ...
Csaba Vastagh, Veronika Csillag, Veronika Csillag, Norbert Solymosi, Imre Farkas, Zsolt Liposits, Zsolt Liposits   +6 more
doaj   +1 more source

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

Frontiers in Pharmacology, 2020
Ischemic/reperfusion (I/R) injury is the primary cause of acute kidney injury (AKI). Gastrin, a gastrointestinal hormone, is involved in the regulation of kidney function of sodium excretion. However, whether gastrin has an effect on kidney I/R injury is
Chao Liu, Chao Liu, Ken Chen, Ken Chen, Huaixiang Wang, Ye Zhang, Ye Zhang, Xudong Duan, Yuanzheng Xue, Yuanzheng Xue, Hongye He, Hongye He, Yu Huang, Yu Huang, Zhi Chen, Zhi Chen, Hongmei Ren, Hongmei Ren, Hongyong Wang, Hongyong Wang, Chunyu Zeng, Chunyu Zeng, Chunyu Zeng, Chunyu Zeng   +23 more
doaj   +1 more source

A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma

BMC Cancer, 2021
Background and aim Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose of this study was to explore the expression profiles of lipid metabolism-related genes (LMRG) in colorectal cancer (CRC).
Chao Yang, Shuoyang Huang, Fengyu Cao, Yongbin Zheng   +3 more
doaj   +1 more source

MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer. [PDF]

PLoS ONE, 2016
MicroRNAs (miRNAs) have been widely accepted as a class of gene expression regulators which post-translationally regulate protein expression. These small noncoding RNAs have been proved closely involved in the modulation of various pathobiological ...
Beiqin Yu, Xin Lv, Liping Su, Jianfang Li, Yingyan Yu, Qinlong Gu, Min Yan, Zhenggang Zhu, Bingya Liu   +8 more
doaj   +1 more source

Transcriptome profiling in rumen, reticulum, omasum, and abomasum tissues during the developmental transition of pre-ruminant to the ruminant in yaks

Frontiers in Veterinary Science, 2023
The development of the four stomachs of yak is closely related to its health and performance, however the underlying molecular mechanisms are largely unknown.
Yili Liu, Qi Min, Jiao Tang, Lu Yang, Xinxin Meng, Tao Peng, Mingfeng Jiang   +6 more
doaj   +1 more source

Elevated CCKBR expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from ...
openaire   +1 more source

Intestinal Cckbr-specific knockout mouse as a novel model of salt-sensitive hypertension via sodium over-absorption

Journal of Geriatric Cardiology, 2023
To investigate the value of CCKBRfl/fl villin-Cre mice as a mouse model of salt-sensitive hypertension (SSH).In the first part, 2-month-old CCKBRfl/fl villin-Cre mice (CKO) and control CCKBRfl/fl mice (WT) were fed with normal diet (0.4% NaCl) or high salt diet (4% NaCl), separately for 6 weeks.
Qiong-Yu, Zhang, Yan, Guo, Xiao-Liang, Jiang, Xing, Liu, Shu-Guang, Zhao, Xian-Liang, Zhou, Zhi-Wei, Yang   +6 more
openaire   +2 more sources

MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation

Molecular Cancer, 2011
Background MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers ...
Jiang Li, Zhang Xue, Xu Hui-Mian, Luo Yang, Xu Ying-Ying, Wang Zhen-Ning, Yue Zhen-Yu, Song Yong-Xi, Xing Cheng-Zhong, Zhang Yong   +9 more
doaj   +1 more source

Molecular Docking Investigation of Dioscorea alata Compounds Binding to CCKBR, CHRM3, CHRM5, and H2R for Gastric Ulcer Treatment

Trends in Sciences, 2023
Gastric ulcer is a pathological condition characterized by damage to the mucosal and submucosal tissue layers of the stomach. The main proteins targeted in the treatment of gastric ulcers are CCKBR, CHRM3, CHRM5, and H2R because of their roles in the regulation of gastric acid secretion. Dioscorea alata (DA) is known to contain various active compounds
Sri Nabawiyati Nurul Makiyah, Sherly Usman, Ahmad Hafidul Ahkam   +2 more
openaire   +1 more source

Regional Functional Molecular Profiles Within the Mammalian Cortex: A Commentary on Limbic Mesocortex

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
Two lateral mouse brain sagittal sections labeled, respectively, for Lypd1 (A) and Kcnab3 (B). (A) Lypd1 labels positively cortical Layers 2 and 5 (less heavily), but only at limbic mesocortical sites, forming the limbic ring that separates the unlabeled isocortex (IsoCx) from the unlabeled hippocampal and olfactory allocortex (Hi, Sub, ERh; OlfCx ...
Luis Puelles, Elena Garcia‐Calero
wiley   +1 more source