Results 51 to 60 of about 87,027 (145)

Wenyang Yiqi Formula improves Na + /H + ion transport by inhibiting NHE3 via activation of gastrin/CCKBR pathway

, 2023
Abstract Background: STC is a common digestive disorder and WYF is a Chinese medicine used to treat it. NHE3 is a protein that helps absorb sodium ions and its inhibition has been linked to various diarrheal diseases. There is little research on the effects of WYF on NHE expression and the treatment of STC, and the mechanism behind it is not ...
Bensheng Wu, Zongqi He, Xiaopeng Wang, Qing Zhou   +3 more
openaire   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

Expression of Cckbr, Gast, Reg1α, Tgfb1 genes in rat pancreas upon long-term hypoacidity and with administration of multiprobiotic «Symbiter® acidophilic» concentrated [PDF]

Biopolymers and Cell, 2012
????????. ?????????????????????? ???????????????????? ?????????? Cckbr, Gast, Reg1?? ?? Tgfb1 ?? ?????????????????????????? ???????????? ???????? ?? ???????????????? ???????????????????? ??????????????????????????, ?? ?????????? ?????? ???????????????? ???????????????????????????????? ???????????????????? ?????????????????????????? ?????????????????????
Vakal, S.E., Dvorshchenko, K.O., Dranitsina, A.S., Borodina, T.V., Ostapchenko, L.I.   +4 more
openaire   +2 more sources

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Endothelin‐Converting Enzyme‐Like 1 Regulated by LIF Contributes to Chronic Constriction Injury‐Induced Neuropathic Pain in Mice

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
After chronic constriction injury (CCI), leukemia inhibitory factor (LIF) is transported from the distal injury site to dorsal root ganglion (DRG) neurons and promotes the expression of ECEL1, thereby promoting sympathetic sprouting and causing neuropathic pain. ABSTRACT Aims This study is to investigate the role of Endothelin‐converting enzyme‐like 1 (
Feng Gao, Yuchen Pan, Yong Huang, Chen Gu, Xiaowei Song, Cunjin Wang   +5 more
wiley   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine TumorsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: In patients with autoimmune atrophic gastritis and achlorhydria, hypergastrinemia is associated with the development of type 1 gastric neuroendocrine tumors (gNETs). Twelve months of treatment with netazepide (YF476), an antagonist
Katie A. Lloyd, Bryony N. Parsons, Michael D. Burkitt, Andrew R. Moore, Stamatia Papoutsopoulou, Malcolm Boyce, Carrie A. Duckworth, Klaire Exarchou, Nathan Howes, Lucille Rainbow, Yongxiang Fang, Claus Oxvig, Steven Dodd, Andrea Varro, Neil Hall, D. Mark Pritchard   +15 more
doaj   +1 more source

Efferocytosis: The Janus‐Faced Gatekeeper of Aging and Tumor Fate

Aging Cell, Volume 24, Issue 2, February 2025.
The multistep process by which phagocytes engulf these deceased cells without eliciting an inflammatory response is called efferocytosis. During aging, the efferocytosis of phagocytes is impaired, which is closely associated with the development of many age‐related diseases.
Zaoqu Liu, Yan Li, Yuqing Ren, Jingqi Chen, Siyuan Weng, Zhaokai Zhou, Peng Luo, Quan Chen, Hui Xu, Yuhao Ba, Anning Zuo, Shutong Liu, Yuyuan Zhang, Teng Pan, Xinwei Han   +14 more
wiley   +1 more source

Suppression of Hippocampal Neurogenesis and Oligodendrocyte Maturation Similar to Developmental Hypothyroidism by Maternal Exposure of Rats to Ammonium Perchlorate, a Gunpowder Raw Material and Known Environmental Contaminant

Environmental Toxicology, Volume 40, Issue 1, Page 30-53, January 2025.
ABSTRACT The environmental contaminant perchlorate raises concern for hypothyroidism‐related brain disorders in children. This study investigated the effects of developmental perchlorate exposure on hippocampal neurogenesis and oligodendrocyte (OL) development.
Yuri Sakamaki, Momoka Shobudani, Ryota Ojiro, Shunsuke Ozawa, Qian Tang, Xinyu Zou, Yuri Ebizuka, Ayumi Karasawa, Gye‐Hyeong Woo, Toshinori Yoshida, Makoto Shibutani   +10 more
wiley   +1 more source

Gastrin signaling in cardiovascular pathophysiology: From molecular crosstalk to clinical implications

Clinical and Experimental Hypertension
As a gastrointestinal hormone, gastrin stimulates gastric acid secretion and intestinal mucosal nutrition. Evidence links it closely to coronary heart disease, ischemia‒reperfusion injury and hypertension.
Chunmei Xu, Zhuxin Li, Yongchun Zeng, Hao Luo, Xuewei Xia   +4 more
doaj   +1 more source