Results 1 to 10 of about 39,125 (240)

Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome

Archives of Medical Science, 2022
Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS).
Eva Drnovsek, Mojca Jensterle, Katja Goričar, Sara Redenšek, Andrej Janež, Irina Milisav, Vita Dolžan   +6 more
doaj   +2 more sources

Structure-activity relationship data and ligand-receptor interactions identify novel agonists consistent with sulfakinin tissue-specific signaling in Drosophila melanogaster heart

Frontiers in Bioscience-Landmark, 2022
Background: The structures and activities of invertebrate sulfakinins that influence gut motility and heart rate are like the vertebrate cholecystokinin (CCK) peptides.
Ruthann Nichols, Chloe Bass, Chris Katanski   +2 more
doaj   +1 more source

Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk

Journal of Lipid Research, 2002
The relationship between obesity and cholesterol cholelithiasis is not well understood at physiologic or genetic levels. To clarify whether obesity per se leads to increased prevalence of cholelithiasis, we examined cholesterol gallstone susceptibility ...
Guylaine Bouchard, Derek Johnson, Tonya Carver, Beverly Paigen, Martin C. Carey   +4 more
doaj   +1 more source

Cholecystokinin and the hormone concept

Endocrine Connections, 2021
The birth certificate for endocrinology was Bayliss’ and Starlin g’s demonstration in 1902 that regulation of bodily functions is not only neuronal but al so due to blood-borne messengers. Starling named these messengers hormones.
Jens F Rehfeld
doaj   +1 more source

Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer

Biomedicines, 2018
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 74–75).
Gail L. Matters, John F. Harms
doaj   +1 more source

Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition

Cell Reports, 2017
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited.
Megan S. Wyeth, Kenneth A. Pelkey, Xiaoqing Yuan, Geoffrey Vargish, April D. Johnston, Steven Hunt, Calvin Fang, Daniel Abebe, Vivek Mahadevan, André Fisahn, Michael W. Salter, Roderick R. McInnes, Ramesh Chittajallu, Chris J. McBain   +13 more
doaj   +1 more source

Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity

Frontiers in Physiology, 2019
Gut-brain signaling controls feeding behavior and energy homeostasis; however, the underlying molecular mechanisms and impact of diet-induced obesity (DIO) on these pathways are poorly defined.
Donovan A. Argueta, Pedro A. Perez, Alexandros Makriyannis, Nicholas V. DiPatrizio   +3 more
doaj   +1 more source

CCK‐1 and CCK‐2 receptor agonism do not stimulate GLP‐1 and neurotensin secretion in the isolated perfused rat small intestine or GLP‐1 and PYY secretion in the rat colon

Physiological Reports, 2020
Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI‐H716) and gastrin ...
Ida M. Modvig, Charlotte B. Christiansen, Jens F. Rehfeld, Jens J. Holst, Simon Veedfald   +4 more
doaj   +1 more source

Gut Hormones and Inflammatory Bowel Disease

Biomolecules
Obesity-driven inflammation disrupts gut barrier integrity and promotes inflammatory bowel disease (IBD). Emerging evidence highlights gut hormones—including glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), glucose-dependent ...
Jonathan Weng, Chunmin C. Lo
doaj   +1 more source

The role of a pre-load beverage on gastric volume and food intake: comparison between non-caloric carbonated and non-carbonated beverage

Nutrition Journal, 2011
Background There is conflicting data on the effects of carbon dioxide contained in beverages on stomach functions. We aimed to verify the effect of a pre-meal administration of a 300 ml non-caloric carbonated beverage (B+CO2) compared to water or a ...
Zito Francesco, Vozzella Letizia, Cirillo Carla, Aragri Adriana, Nicolai Emanuele, Sarnelli Giovanni, Savarese Maria, Cuomo Rosario, Verlezza Viviana, Efficie Eleonora, Buyckx Maxime   +10 more
doaj   +1 more source