Results 41 to 50 of about 55,036 (230)

The Lipids and Volume in Satiation and Satiety (LIVES) Hypothesis: A Proposed Alternative Model for the Pathogenesis of Obesity

Diabetology, 2023
Obesity is one of the most important factors responsible for the marked increase in both the incidence and prevalence of type 2 diabetes mellitus (T2DM) in recent decades.
Andrew Warrilow, Kate Pumpa, Shawn Somerset, Nenad Naumovski   +3 more
doaj   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Is fat the sixth taste primary? Evidence and implications [PDF]

, 2015
Explores our tongue\u27s ability to detect fat as a distinct taste similar to our ability to sense sweet, sour, bitter, acid and savory. Abstract Taste is the chemical sense responsible for the detection of non-volatile chemicals in potential foods. For
Andrew Costanzo, Russell Keast
core   +1 more source

Oxytocin‐ und Vasopressin‐Photosonden zur Entschlüsselung der Neuropeptid‐Signalgebung mit hoher räumlicher und zeitlicher Präzision

Angewandte Chemie, EarlyView.
Neue biokompatible Oxytocin‐ und Vasopressin‐Photosonden mit modernsten Photocages. Diese Photosonden sind inaktiv und können mit spezifischen Lichtwellen entschützt werden, was eine Rezeptoraktivierung mit hoher zeitlicher und räumlicher Kontrolle ermöglicht. Abbildung erstellt mit https://BioRender.com ZUSAMMENFASSUNG Das Oxytocin/Vasopressin (OT/VP)
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Complementary roles of Cholecystokinin- and Parvalbumin-expressing GABAergic neurons in hippocampal network oscillations [PDF]

, 2005
In the hippocampal CA1 area, a relatively homogenous population of pyramidal cells is accompanied by a diversity of GABAergic interneurons. Previously, we found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum moleculare
Csicsvari, Jozsef, Dalezios, Yannis, Fuentealba, Pablo, Huck, Jojanneke H. J., Kaneko, Takeshi, Klausberger, T, Marton, Laszlo F., O'Neill, Joseph, Papp, Edit, Somogyi, Peter, Suen, Wai Yee, Watanabe, Masahiko   +11 more
core   +2 more sources

Unethical informed consent caused by overlooking poorly measured nocebo effects [PDF]

, 2020
Unlike its friendly cousin the placebo effect, the nocebo effect (the effect of expecting a negative outcome) has been almost ignored. Epistemic and ethical confusions related to its existence have gone all but unnoticed.
Howick, Jeremy
core   +1 more source

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Frontiers in Endocrinology, 2021
Drugs useful in prevention/treatment of obesity could improve health. Cholecystokinin (CCK) is a key regulator of appetite, working through the type 1 CCK receptor (CCK1R); however, full agonists have not stimulated more weight loss than dieting.
Kaleeckal G. Harikumar, Thomas Coudrat, Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness, Arthur Christopoulos, Arthur Christopoulos, Denise Wootten, Denise Wootten, Eduard A. Sergienko, Patrick M. Sexton, Patrick M. Sexton, Laurence J. Miller   +14 more
doaj   +1 more source

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source