Results 21 to 30 of about 28,880 (163)

Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer

Biomedicines, 2018
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 74–75).
Gail L. Matters, John F. Harms
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Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition

Cell Reports, 2017
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited.
Megan S. Wyeth, Kenneth A. Pelkey, Xiaoqing Yuan, Geoffrey Vargish, April D. Johnston, Steven Hunt, Calvin Fang, Daniel Abebe, Vivek Mahadevan, André Fisahn, Michael W. Salter, Roderick R. McInnes, Ramesh Chittajallu, Chris J. McBain   +13 more
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Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens [PDF]

Archives of Razi Institute, 2022
This study aimed to assess the possible feeding behavior alterations by central interactions of cholecystokinin (CCK) and glutamatergic systems in neonatal chickens.
M Jelokhani, B Vazir, M Zendehdel, A Jahandideh   +3 more
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Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity

Frontiers in Physiology, 2019
Gut-brain signaling controls feeding behavior and energy homeostasis; however, the underlying molecular mechanisms and impact of diet-induced obesity (DIO) on these pathways are poorly defined.
Donovan A. Argueta, Pedro A. Perez, Alexandros Makriyannis, Nicholas V. DiPatrizio   +3 more
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CCK‐1 and CCK‐2 receptor agonism do not stimulate GLP‐1 and neurotensin secretion in the isolated perfused rat small intestine or GLP‐1 and PYY secretion in the rat colon

Physiological Reports, 2020
Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI‐H716) and gastrin ...
Ida M. Modvig, Charlotte B. Christiansen, Jens F. Rehfeld, Jens J. Holst, Simon Veedfald   +4 more
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Gut Hormones and Inflammatory Bowel Disease

Biomolecules
Obesity-driven inflammation disrupts gut barrier integrity and promotes inflammatory bowel disease (IBD). Emerging evidence highlights gut hormones—including glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), glucose-dependent ...
Jonathan Weng, Chunmin C. Lo
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The role of a pre-load beverage on gastric volume and food intake: comparison between non-caloric carbonated and non-carbonated beverage

Nutrition Journal, 2011
Background There is conflicting data on the effects of carbon dioxide contained in beverages on stomach functions. We aimed to verify the effect of a pre-meal administration of a 300 ml non-caloric carbonated beverage (B+CO2) compared to water or a ...
Zito Francesco, Vozzella Letizia, Cirillo Carla, Aragri Adriana, Nicolai Emanuele, Sarnelli Giovanni, Savarese Maria, Cuomo Rosario, Verlezza Viviana, Efficie Eleonora, Buyckx Maxime   +10 more
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BRAIN CHOLECYSTOKININ SYSTEM IN NEUROTIC PATHOLOGY

Проблеми екології та медицини, 2023
Violation and discoordination of mental processes leads to changes in the ratio of the main neurotransmitters content and further to mental disorders. A significant role in such processes is played by neuropeptides, in particular anti-anxiety ones, which
R.V. Lutsenko, A.V. Vakhnenko, G.Yu. Ostrovska, N.V. Moiseieva, O.A. Lutsenko   +4 more
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The Lipids and Volume in Satiation and Satiety (LIVES) Hypothesis: A Proposed Alternative Model for the Pathogenesis of Obesity

Diabetology, 2023
Obesity is one of the most important factors responsible for the marked increase in both the incidence and prevalence of type 2 diabetes mellitus (T2DM) in recent decades.
Andrew Warrilow, Kate Pumpa, Shawn Somerset, Nenad Naumovski   +3 more
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Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Frontiers in Endocrinology, 2021
Drugs useful in prevention/treatment of obesity could improve health. Cholecystokinin (CCK) is a key regulator of appetite, working through the type 1 CCK receptor (CCK1R); however, full agonists have not stimulated more weight loss than dieting.
Kaleeckal G. Harikumar, Thomas Coudrat, Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness, Arthur Christopoulos, Arthur Christopoulos, Denise Wootten, Denise Wootten, Eduard A. Sergienko, Patrick M. Sexton, Patrick M. Sexton, Laurence J. Miller   +14 more
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