Results 21 to 30 of about 39,125 (240)
European Psychiatry, 2022 Introduction The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily.
O. Dorofeeva +3 more
doaj +1 more source
Intestinal microbiome dysbiosis in alcohol-dependent patients and its effect on rat behaviors
mBio, 2023 Alcohol dependence (AD) is a worldwide epidemic of psychiatric disorders. Gut microbiota dysbiosis may be involved in the development of AD. Recently, the number of studies on the relationship between gut microbiota and alcohol is increasing.
Chuansheng Wang +10 more
doaj +1 more source
Biomolecules, 2020 Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations.
Ewa Gibula-Tarlowska +1 more
doaj +1 more source
Animals, 2023 The light spectrum is a key environmental cue involved in growth and reproduction in teleosts. This study investigated the effects of exposure on juvenile red spotted grouper exposed to white (control), red (590 nm), blue (480 nm), and green (520 nm ...
Wengang Xu +4 more
doaj +1 more source
Frontiers in Veterinary Science, 2022 Due to the poor palatability of straw, feeding untreated rice straw reduces ruminant feed intake, thus affecting the production efficiency of animal husbandry.
Xi Chen +4 more
doaj +1 more source
eLife, 2023 Nociception is a neural process that animals have developed to avoid potentially tissue-damaging stimuli. While nociception is triggered in the peripheral nervous system, its modulation by the central nervous system is a critical process in mammals ...
Izumi Oikawa +7 more
doaj +1 more source
Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion [PDF]
, 2010 Context: Glucagon-like peptide-1 (GLP-1) is produced by specialized cells in the gut and secreted in response to carbohydrates and lipids. The mechanisms regulating fat-stimulated GLP-1 release have, however, not been clarified in detail.
Schirra, Joerg +5 more
core +1 more source
The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review
Frontiers in Psychiatry, 2020 Functional dyspepsia (FD) and gastroparesis (GP) are common disorders of the upper gastrointestinal tract. The pathophysiology of these conditions is likely to be heterogenous, and factors such as altered motility, sensitivity and response to nutrition ...
Karen Van den Houte +7 more
doaj +1 more source
Membranes, 2023 As part of an ongoing effort to develop a drug targeting the type 1 cholecystokinin receptor (CCK1R) to help prevent and/or treat obesity, we recently performed a high throughput screening effort of small molecules seeking candidates that enhanced the ...
Daniela G. Dengler +4 more
doaj +1 more source
Regulation of fat-stimulated neurotensin secretion in healthy subjects [PDF]
, 2008 CONTEXT: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis is crucial for triggering the release.
Drewe, J. +3 more
core +1 more source