Results 11 to 20 of about 87,027 (145)

CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition [PDF]

Cell Death and Differentiation
The existence of heterogeneity has plunged cancer treatment into a challenging dilemma. We profiled malignant epithelial cells from 5 gastric adenocarcinoma patients through single-cell sequencing (scRNA-seq) analysis, demonstrating the heterogeneity of gastric adenocarcinoma (GA), and identified the CCKBR+ stem cell-like cancer cells associated poorly
Zhenya Tan, Hong Zheng, Chen Kan
exaly   +4 more sources

Therapeutic Response of CCKBR-Positive Tumors to Combinatory Treatment with Everolimus and the Radiolabeled Minigastrin Analogue [¹⁷⁷Lu]Lu-PP-F11N [PDF]

Pharmaceutics, 2021
The inhibition of the mammalian target of rapamycin complex 1 (mTORC1) by everolimus (RAD001) was recently shown to enhance the tumor uptake of radiolabeled minigastrin.
Michal Grzmil, Stefan Imobersteg, Alain Blanc, Stephan Frank, Roger Schibli, Martin P. Béhé   +5 more
doaj   +4 more sources

Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling [PDF]

BMC Cancer, 2018
Background Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, but how its function affects ...
Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han, Guo-Hui Fu   +7 more
doaj   +3 more sources

Comprehensive multi‐omics analysis of resectable locally advanced gastric cancer: Assessing response to neoadjuvant camrelizumab and chemotherapy in a single‐center, open‐label, single‐arm phase II trial

Clinical and Translational Medicine
Background The current standard of care for locally advanced gastric cancer (GC) involves neoadjuvant chemotherapy followed by radical surgery. Recently, neoadjuvant treatment for this condition has involved the exploration of immunotherapy plus ...
Yuzhou Zhao, Danyang Li, Jing Zhuang, Zhimeng Li, Qingxin Xia, Zhi Li, Juan Yu, Jinbang Wang, Yong Zhang, Ke Li, Shuning Xu, Sen Li, Pengfei Ma, Yanghui Cao, Chenyu Liu, Chunmiao Xu, Zhentian Liu, Jinwang Wei, Chengjuan Zhang, Lei Qiao, Xuan Gao, Zhiguo Hou, Chenxuan Liu, Rongrong Zheng, Du Wang, Ying Liu   +25 more
doaj   +2 more sources

Animal models of hypertension and concurrent organs injury. [PDF]

Animal Model Exp Med
Although hypertension is a frequently seen chronic condition across the world, its exact cause remains unclear. Animal models are beneficial for clarifying the pathogenic mechanism of hypertension and examining new treatments. An optimal animal model for studies on hypertension must well mimic human‐like hemodynamics and pathophysiological structural ...
Wang Y, Jiang X, Yang Z.
europepmc   +2 more sources

The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion. [PDF]

PLoS ONE, 2016
Renal dopamine D1-like receptors (D1R and D5R) and the gastrin receptor (CCKBR) are involved in the maintenance of sodium homeostasis. The D1R has been found to interact synergistically with CCKBR in renal proximal tubule (RPT) cells to promote ...
Xiaoliang Jiang, Wei Chen, Xing Liu, Zihao Wang, Yunpeng Liu, Robin A Felder, John J Gildea, Pedro A Jose, Chuan Qin, Zhiwei Yang   +9 more
doaj   +1 more source

Effect of GRK4 on renal gastrin receptor regulation in hypertension

Clinical and Experimental Hypertension, 2023
Objective To investigate whether GRK4 regulates the phosphorylation and function of renal CCKBR. Methods GRK4 A142V transgenic mice were used as an animal model of enhanced GRK4 activity, and siRNA was used to silence the GRK4 gene to investigate the ...
Xuewei Xia, Yongchun Zeng, Zhuxin Li, Hao Luo, Wei Wang, Yanji He, Bingjun Lu, Jingwen Guo, Ken Chen, Xiang Xu   +9 more
doaj   +1 more source

Expression of gastrin and cholecystokinin B receptor in Lateolabrax maculatus

Aquaculture and Fisheries, 2023
Gastrin (gas) is a peptide hormone that stimulates gastric acid secretion by gastric parietal cells and stimulates gastric motility. The cholecystokinin B receptor (cckbr) can act as a receptor for gastrin, conveying regulatory information on gastrin ...
Tingwen Cui, Jiaqi Wang, Zhongjun Hu, Xiaowu Chen   +3 more
doaj   +1 more source

Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages

Acta Pharmaceutica Sinica B, 2023
Myocardial dysfunction is the most serious complication of sepsis. Sepsis-induced myocardial dysfunction (SMD) is often associated with gastrointestinal dysfunction, but its pathophysiological significance remains unclear.
Dandong Fang, Yu Li, Bo He, Daqian Gu, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Ming Tang, Xingbing Li, Donghai Yang, Chunmei Xu, Yijie Hu, Hongyong Wang, Pedro A. Jose, Yu Han, Chunyu Zeng   +17 more
doaj   +1 more source

Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome

Archives of Medical Science, 2022
Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS).
Eva Drnovsek, Mojca Jensterle, Katja Goričar, Sara Redenšek, Andrej Janež, Irina Milisav, Vita Dolžan   +6 more
doaj   +1 more source