Results 21 to 30 of about 87,027 (145)

Evaluation of Actinium-225 Labeled Minigastrin Analogue [²²⁵Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy

Pharmaceutics, 2020
The overexpression of cholecystokinin B receptor (CCKBR) in human cancers led to the development of radiolabeled minigastrin analogues for targeted radionuclide therapy, which aims to deliver cytotoxic radiation specifically to cancer cells.
Yun Qin, Stefan Imobersteg, Alain Blanc, Stephan Frank, Roger Schibli, Martin P. Béhé, Michal Grzmil   +6 more
doaj   +1 more source

Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH-RH in Teleosts. [PDF]

Bioessays
Regarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Kayo D, Uehara SK, Royan MR, Kanda S.
europepmc   +2 more sources

Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)

Journal of Hematology & Oncology, 2022
The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged from studies using external beam radiation therapy (EBRT).
Michal Grzmil, Paul Boersema, Ashish Sharma, Alain Blanc, Stefan Imobersteg, Martin Pruschy, Paola Picotti, Roger Schibli, Martin Behe   +8 more
doaj   +1 more source

Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease. [PDF]

Biofactors
The cholecystokinin and its receptors exhibit extensive expression throughout the brain, where they engage in interactions with various neurotransmitters. They play a crucial role in regulating behavioral phenotypes by modulating neuronal activities and plasticity in region‐specific or circuit‐specific manners.
Asim M, Wang H, Waris A, Qianqian G, Chen X.   +4 more
europepmc   +2 more sources

Development of an exosome-related and immune microenvironment prognostic signature in colon adenocarcinoma

Frontiers in Genetics, 2022
Background: The correlation between exosomes and the tumor immune microenvironment has been proved to affect tumorigenesis and progression of colon adenocarcinoma (COAD).
Guoliang Cui, Can Wang, Jinhui Liu, Kinyu Shon, Renjun Gu, Cheng Chang, Lang Ren, Fei Wei, Zhiguang Sun   +8 more
doaj   +1 more source

Identification of potential biomarkers for abdominal pain in IBS patients by bioinformatics approach

BMC Gastroenterology, 2021
Background Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disease characterized by chronic abdominal discomfort and pain. The mechanisms of abdominal pain, as a relevant symptom, in IBS are still unclear.
Zhongyuan Lin, Yimin Wang, Shiqing Lin, Decheng Liu, Guohui Mo, Hui Zhang, Yunling Dou   +6 more
doaj   +1 more source

Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro.

PLoS ONE, 2019
Gastrin is a peptide hormone, which in combination with other factors such as TGFα, EGF or GLP-1, is capable of increasing beta cell mass and lowering blood glucose levels in adult diabetic mice.
Ayelet Lenz, Gal Lenz, Hsun Teresa Ku, Kevin Ferreri, Fouad Kandeel   +4 more
doaj   +1 more source

Exploring the Differential Expression of a Set of Key Genes Involved in the Regulation and Functioning of the Stomach in the Post-Weaned Pig

Veterinary Sciences, 2023
Despite playing a key role in digestion, there is only a broad characterization of the spatiotemporal development of the three glandular regions of the stomach (cardiac, fundic and pyloric) in the weaned pig.
Dillon P. Kiernan, John V. O’Doherty, Kathryn Ruth Connolly, Marion Ryan, Torres Sweeney   +4 more
doaj   +1 more source

Polymorphic variants of the cholecystokinergic system genes: associations with panic disorders

Медицинский совет, 2018
Panic disorder is a widespread socially significant disease, which genetic nature is extremely poorly known. The gene of this neuropeptide (CCK) and its receptors (CCKAR, CCK2R) have being actively studied since the discovery of panicogenic properties of
E. A. Klimov, A. V. Malakhova, L. A. Korobeinikova, Yu. E. Azimova, O. I. Rudko, Z. G. Kokaeva, I. M. Korsunskaya, V. V. Sobolev   +7 more
doaj   +1 more source

Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®” [PDF]

The Ukrainian Biochemical Journal, 2013
The intensity of free-radical processes upon long-term omeprazole-induced hypoacidity in the rat pancreas was investigated. Significant violation of oxidative-antioxidative balance in pancreatic tissue upon gastric hypochlorhydria was established ...
K. O. Dvorshchenko, S. Ye. Vakal, A. S. Dranitsina, S. A. Senin, L. I. Ostapchenko   +4 more
doaj   +1 more source