Results 101 to 110 of about 74,881 (294)

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

open access: yesAdvanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan   +9 more
wiley   +1 more source

Multilevel Fixed and Sequential Acceptance Sampling: The R Package MFSAS

open access: yesJournal of Statistical Software, 2011
Multilevel acceptance sampling for attributes is used to decide whether a lot from an incoming shipment or outgoing production is accepted or rejected when the product has multiple levels of product quality or multiple types of (mutually exclusive ...
Aaron Childs, Yalin Chen
doaj  

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

open access: yesAdvanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

open access: yesAdvanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang   +14 more
wiley   +1 more source

Distribution of LRC for testing sphericity of a complex multivariate Gaussian model

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1985
In this paper, exact null distribution of the likelihood ratio criterion for testing sphericity structure in a complex multivariate normal covariance matrix is obtained in computable series form.
D. K. Nagar, S. K. Jain, A. K. Gupta
doaj   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

open access: yesAdvanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang   +17 more
wiley   +1 more source

A New Double Weighted Fuzzy Hypergeometric Naive Bayes Network and its Application for User’s Assessment in Virtual Reality Simulators

open access: yesInternational Journal of Computational Intelligence Systems
Assessment methods have been used for identify the quality of procedures performed by human beings. In virtual reality simulators, user’s interaction data can be collected and utilized by Single User Assessment Systems (SUAS) to assess the user’s ...
Jodavid Ferreira   +2 more
doaj   +1 more source

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