Results 111 to 120 of about 5,110,179 (281)

Transcriptome and proteome analyses reveal divergent adaptive strategies in nasopharyngeal epithelial cells and nasopharyngeal carcinoma cells under ultra‐low background radiation

Deep Underground Science and Engineering, EarlyView.
This study demonstrates that the ultra‐low background radiation environment in deep underground laboratories significantly inhibits the proliferation of both normal nasopharyngeal epithelial cells (HNEPC) and nasopharyngeal carcinoma cells (HNE‐1) cells, with malignant cells exhibiting higher sensitivity.
Yuhao Zou, Qi Wu, Jirui Wen, Ling Wang, Can Li, Juan Cheng, Tengfei Ma, Chuhan Lv, Shixi Liu, Mingzhong Gao, Ruihua Dong, Jianxiong Zhang, Jingxuan Wu, Heping Xie, Jiang Wu, Jifeng Liu   +15 more
wiley   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

Epilepsia Open, EarlyView.
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher, Mathias Woidy, Franziska Plein, Tatjana Bierhals, Leonie von Elsner, Theresia Herget, Maja Hempel, Fanny Kortüm, Lev Grinstein, Julia V. Cramer, Jessika Johannsen, Jonas Denecke   +11 more
wiley   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

A Note About Maximum Likelihood Estimator in Hypergeometric Distribution

Hypergeometric distribution, maximum likelihood ...
Hanwen Zhang
core  

Confluent hypergeometric slashed-Rayleigh distribution: Properties, estimation and applications

, 2021
This article proposes a new distribution, the Confluent hypergeometric slashed-Rayleigh distribution. The new distribution can be seen as an alternative to the slashed-Rayleigh distribution.
Gomez, Yolanda M., Iriarte, Yuri A., Olmos, Neveka M., Venegas, Osvaldo   +3 more
core  

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Minimax Prediction for the Multinomial and Multivariate Hypergeometric Distributions [PDF]

, 1998
A problem of minimax prediction for the multinomial and multivariate hypergeometric distribution is considered. A class of minimax predictors is determined for estimating linear combinations of the unknown parameter and the random variable having the ...
Jokiel-Rokita, Alicja
core  

Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection

iMeta, EarlyView.
This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu, Xiuying Tao, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +5 more
wiley   +1 more source

From Finding a Spanning Subgraph H $H$ to an H $H$‐Factor

Journal of Graph Theory, EarlyView.
ABSTRACT A typical Dirac‐type problem in extremal graph theory is to determine the minimum degree threshold for a graph G $G$ to have a spanning subgraph H $H$, for example, the Dirac theorem. A natural follow‐up problem is to seek an H $H$‐factor, which is a spanning set of vertex‐disjoint copies of H $H$.
Allan Lo
wiley   +1 more source

Estimating Sensitive Population Proportion by Generating Randomized Response Following Direct and Inverse Hypergeometric Distribution

, 2016
We consider estimating the proportion of people containing sensitive attributes like habitual drunkenness, drug addiction, reckless car driving, evading the tax liabilities, etc., in a given community.
Dihidar, K., K. Dihidar
core   +1 more source