Results 131 to 140 of about 5,110,179 (281)

Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk

Integrative Zoology, EarlyView.
The dog is a valuable model for studying social behavior and neuropsychiatric disease. We generated an ATAC‐seq atlas of 7 brain regions and pituitary from 4 beagles, identifying 251,492 CREs. Integrating dog‐wolf divergence revealed tissue‐specific CREs overlapping divergent loci, including neuronal and neuroendocrine genes.
Biao Deng, Junze Wu, Ye Liu, Xuan Li, Yuanfang Xu, Rongjie Duan, Yibo Tong, Jinsheng Xu, Mengyang Ni, Zijie Scott Zhang, Dan Xue, Bowen Zhou, Yanhu Liu, Rui Cheng, Yuedong Zhang, Ya‐Ping Zhang   +15 more
wiley   +1 more source

ggNetView: An R package for reproducible biological network analysis and visualization

Methods in Ecology and Evolution, EarlyView.
Abstract Biological network analysis has become an important approach for investigating interactions among microorganisms, genes, proteins, and environmental variables across ecology, microbiology, and molecular biology. In practice, however, turning an inferred network into a clear figure and a full set of downstream topology and module analyses ...
Yue Liu, Chao Wang
wiley   +1 more source

Multi‐Omics Analysis Reveals Vitamin D Metabolism, Hyper‐IgE Genes, and Epithelial Barrier Dysfunction in Hazelnut Allergy

Allergy, EarlyView.
Multi‐omics profiling of hazelnut‐allergic versus nonallergic individuals identified 87 differentially methylated signals, 125 differentially expressed genes, and 11 differentially secreted proteins. Among these were ZNF341 and ARL2 (STAT3‐mediated hyper‐IgE dysregulation), alongside epithelial barrier (TRIM31, TRIM40, CDSN) and vitamin D pathway ...
Alexander C. S. N. Jeanrenaud, Aleix Arnau‐Soler, Ahla Ghauri, Ingo Marenholz, Philipp Mertins, Matthias Ziehm, Kirsten Beyer, Margitta Worm, Young‐Ae Lee   +8 more
wiley   +1 more source

P A AN IMPROVED NEGATIVE BINOMIAL DISTRIBUTION TO APPROXIMATE THE NEGATIVE HYPERGEOMETRIC DISTRIBUTION

, 2014
: We give an improved negative binomial distribution with parameters r and p for approximating the negative hypergeometric distribution with parameters R, S and r, where p = 1 − q = R+1 R+S+1 .
K Teerapabolarn
core  

Integrated Analysis of HER2 Expression and ERBB2 Alterations in Bladder Cancer

Cancer Science, EarlyView.
Integrated analysis of 445 bladder cancers showed that HER2 membrane expression and ERBB2 amplification are distinct features. HER2 expression overlapped with NECTIN4 expression, whereas ERBB2 amplification was enriched in the LumU subtype and associated with poor prognosis.
Kensuke Hirosuna, Kazuki Nishimura, Moritoshi Sakamoto, Satoshi Tokushige, Keita Nakamori, Tomohisa Matsunaga, Yuki Yoshikawa, Takeshi Tsutsumi, Ryoichi Maenosono, Takuya Tsujino, Masahiko Ajiro, Haruhito Azuma, Akihide Yoshimi, Kazumasa Komura   +13 more
wiley   +1 more source

Hypergeometric family and item overlap rates in computerized adaptive testing

computerized adaptive testing, hypergeometric distribution, item exposure rate, item selection, stratification, Sympson-Hetter method, item overlap rate, test security,
Jinming Zhang, Hua-Hua Chang
core   +1 more source

Circles of Confidence for Multi‐Label Geometry Completion

Computer Graphics Forum, EarlyView.
Abstract Inside–outside classification is widely used for geometry processing tasks such as surface reconstruction, geometry completion, and calculating signed distance fields. We introduce a new integral formulation of this problem, which assigns confidence scores that points are inside or outside, given incomplete boundary geometry.
Z. Wei, C. Hafner, A. Kalinov, P. Heiss‐Synak, C. Wojtan   +4 more
wiley   +1 more source

Single‐Cell and Spatial Analysis Reveal the Differences Between Left‐Sided and Right‐Sided Colorectal Cancer

Cell Proliferation, EarlyView.
Single‐cell and spatial analysis revealed distinct CRC microenvironments by tumour laterality. Right‐sided tumours showed enhanced germinal centre B cells, CXCL13+ T cells, and organized TLS‐immune crosstalk via CCL19/21‐CCR7, suggesting better immunotherapy response.
Zongnai Zhang, Jiaqi Xu, Yingchao Wu, Tao Liu, Junling Zhang, Mai Zhou, Jie Qiao, Heng Pan, Xin Wang   +8 more
wiley   +1 more source

Properties of the hypergeometric function type I distribution

, 2005
: The hypergeometric function type I distribution with the pdf proportional to x () ( ) − x F α β γ − x ν− γ− 1 2 1 , ; ; 1 1 1 occurs as the distribution of the product of two independent beta variables. In this article, we study several properties and
Álvarez Chalarca, José Ángel, Nagar, Daya Krishna   +1 more
core  

The transport of protein aggregates to the vacuole suggests a role for lipid droplets in waste disposal in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
Lipid droplets (LD) act as cellular ‘garbage trucks’ that transport cytosolic protein aggregates to the vacuole for degradation in yeast. Protein aggregates are docked to lipid droplets in a triacylglycerol‐dependent manner, transported through the cytoplasm, and transferred to the insoluble protein deposit (IPOD) at the vacuole.
Christoph Reiter, Patrick Ebner, Elli Leona Kronsteiner, Sophia Moustakakis, Markus Wiederstein, Astrid Obermayer, Ronald Thomas Huber, Christian Schloegelhofer, Florian Wieser, Jon Cedrick Richter, Isabelle Guirsch, Patrick Rockenfeller, Jana Vojtová, Tomáš Groušl, Thomas Klaus Felder, Mark Rinnerthaler   +15 more
wiley   +1 more source