Results 131 to 140 of about 6,151,667 (279)

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

Non-null Distribution of The Likelihood Ratio Statistic for Testing Multisample Compound Symmetry

Revista Integración, 2004
The non-null distribution of the modified likelihood ratio test statistic Λ∗ for testing multisample compound symmetry of q multivariate Gaussian models is derived.
María E. Castañeda, Daya K. Nagar
doaj  

The Lipidomic Profile Discriminates Between MASLD and MetALD

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1357-1371, April 2025.
HDL‐centric lipidomic biomarkers, particularly within large and medium HDL subfractions, distinguish metabolic dysfunction and alcohol‐related liver disease from metabolic dysfunction‐associated steatotic liver disease, suggesting potential biomarkers for clinical differentiation.
Kai Markus Schneider, Feng Cao, Helen Ye Rim Huang, Lanlan Chen, Yazhou Chen, Rongpeng Gong, Anastasia Raptis, Kate Townsend Creasy, Jan Clusmann, Felix van Haag, Paul‐Henry Koop, Adrien Guillot, Tom Luedde, Rohit Loomba, Sven Francque, Carolin Victoria Schneider   +15 more
wiley   +1 more source

Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex

Brain Pathology, Volume 35, Issue 3, May 2025.
This study analyzes four public transcriptome datasets from AD patients and age‐matched controls, revealing that the transcriptomic profile in female controls closely resembles that of AD patients. We identified a co‐expressed gene module associated with AD, sex, and aging, enriched with immune‐related functions.
Huiying Wen, Youzhe He, Yuanchun Tang, Langjian Zhu, Quyuan Tao, Bufan Jin, Ting Luo, Yujie Peng, Yanrong Wei, Junjie Lei, Lifang Wang, Fan Wang, Fei Ling, Yue Gao, Lei Han   +14 more
wiley   +1 more source

Chi-Square Approximation for the Distribution of Individual Eigenvalues of a Singular Wishart Matrix

Mathematics
This paper discusses the approximate distributions of eigenvalues of a singular Wishart matrix. We give the approximate joint density of eigenvalues by Laplace approximation for the hypergeometric functions of matrix arguments.
Koki Shimizu, Hiroki Hashiguchi
doaj   +1 more source

OCT‐2 Is Associated With Pro‐Metastatic Epigenomic Properties of Triple‐Negative Breast Cancer Cells

Cancer Science, EarlyView.
The transcription factor OCT‐2 (encoded by POU2F2) is involved in the formation of super‐enhancers (SEs) in triple‐negative breast cancer (TNBC) cells. Overexpression of POU2F2 enhances the metastasis of TNBC cells in mice, and their expression is highly correlated to the poor prognosis of TNBC patients. ABSTRACT Triple‐negative breast cancer (TNBC) is
Kazuki Ogikubo, Jun Nishida, Kei Takahashi‐Yamashiro, Masato Morikawa, Shogo Ehata, Tetsuro Watabe, Kohei Miyazono, Daizo Koinuma   +7 more
wiley   +1 more source

A Case‐Driven Multi‐Omics Analysis for Longitudinal Ibrutinib Response Evaluation of Patients With Chronic Lymphocytic Leukemia

European Journal of Haematology, Volume 114, Issue 6, Page 973-981, June 2025.
ABSTRACT Patients with chronic lymphocytic leukemia (CLL) undergoing ibrutinib treatment often experience incomplete response, yet the molecular level underlying clonal inertia remains to be explored. We investigated the molecular and clinical dynamics of CLL during 16 months of ibrutinib monotherapy by analyzing blood samples from two patients who ...
Sólja Remisdóttir Veyhe, Marcus Høy Hansen, Oriane Cédile, Michael Boe Møller, Mie Kiszka Nielsen, Mads Thomassen, Karen Juul‐Jensen, Henrik Frederiksen, Karen Dybkær, Charlotte Guldborg Nyvold   +9 more
wiley   +1 more source

Clebsch-Gordan coefficients, hypergeometric functions and the binomial distribution [PDF]

arXiv
A particular case of degenerate Clebsch-Gordan coefficient can be expressed with three binomial coefficients. Such a formula, which may be obtained using the standard ladder operator procedure, can also be derived from the Racah-Shimpuku formula or from expressions of Clebsch-Gordan coefficients in terms of $_3F_2$ hypergeometric functions.
arxiv  

Transcriptomic signatures and network‐based methods uncover new senescent cell anti‐apoptotic pathways and senolytics

The FEBS Journal, Volume 292, Issue 8, Page 1950-1971, April 2025.
This study identifies new senescent cell antiapoptotic pathways (SCAPs) by analyzing transcriptomic signatures and co‐expression networks. We uncover novel antiapoptotic pathways, called SCAPs, and propose potential senolytic drugs, including Fluorouracil, which targets key SCAPs.
Samael Olascoaga, Mina Konigsberg, Jesús Espinal‐Enríquez, Hugo Tovar, Félix Matadamas‐Martínez, Jaime Pérez‐Villanueva, Norma Edith López‐Diazguerrero   +6 more
wiley   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source