Results 221 to 230 of about 74,881 (294)

FunFEA: an R package for fungal functional enrichment analysis. [PDF]

BMC Bioinformatics
Charest J, Loebenstein P, Mach RL, Mach-Aigner AR.   +3 more
europepmc   +1 more source

An Improved Bayesian Pick‐the‐Winner (IBPW) Design for Randomized Phase II Clinical Trials

Statistics in Medicine, Volume 45, Issue 1-2, January 2026.
ABSTRACT Phase II clinical trials play a pivotal role in drug development by screening a large number of drug candidates to identify those with promising preliminary efficacy for phase III testing. Trial designs that enable efficient decision‐making with small sample sizes and early futility stopping while controlling for type I and type II errors in ...
Wanni Lei, Maosen Peng, Nasser Altorki, Xi Kathy Zhou   +3 more
wiley   +1 more source

Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons. [PDF]

PLoS Genet
Cuvertino S, Martirosian E, Bhosale K, Cheng P, Garner T, Donaldson IJ, Jackson A, Stevens A, Sharrocks AD, Kimber SJ, Banka S.   +10 more
europepmc   +1 more source

Nano MiRNA‐Functionating Tetrahedral Framework Nucleic Acid for Cartilage‐Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis

Small Science, Volume 6, Issue 1, January 2026.
Current temporomandibular joint osteoarthritis (TMJOA) treatments lack progression control. MicroRNAs (miRNAs) offer therapeutic potential but face delivery hurdles. A novel nanodelivery system is developed using tetrahedral framework nucleic acids functionalized with miR‐143‐3p (tFNAs‐143). Tested in TMJOA models and inflammatory conditions, tFNAs‐143
Wenxiu Yuan, Maotuan Huang, Linxin Chen, Sihang Chen, Hanyu Lin, Nengwen Huang, Yifeng Xing, Chengchaozi Wang, Jie Lu, Min Fu, Linyu Xu, Jiang Chen   +11 more
wiley   +1 more source

Mapping the transcriptional regulatory network of a fungal pathogen by exploiting transcription factor perturbation. [PDF]

mBio
Abid D, Brown H, Mateusiak C, Doering TL, Brent MR.   +4 more
europepmc   +1 more source

Ancestral Origin and Structural Characteristics of Non‐Syntenic Homologous Chromosomes in Abalones (Haliotis)

Molecular Ecology Resources, Volume 26, Issue 1, January 2026.
ABSTRACT Structural variation is increasingly recognised as a pivotal contributor to genomic diversity in marine invertebrates, yet its extent and evolutionary significance remain poorly characterised in many species. Haplotype‐phased genome assembly is an excellent resource for studying such variations by comparing homologous chromosomes.
Shotaro Hirase, Takashi Makino, Takeshi Takeuchi, Mitsutaka Kadota, Shigehiro Kuraku, Kiyoshi Kikuchi   +5 more
wiley   +1 more source

DENetwork unveils non-differentially expressed genes with functional relevance across conditions through information flow perturbation. [PDF]

Nucleic Acids Res
Zhao B, Su TY, Wang J, Islam QS, Song K, Huang SK, Allez M, Fonseca GJ, Baglole CJ, Ding J.   +9 more
europepmc   +1 more source

Estimating Unknown Population Sizes Using the Hypergeometric Distribution [PDF]

L. M. Hodgson, Danilo Bzdok
openalex   +1 more source

Atavistic Genetic Expression Dissociation (AGED) During Aging: Meta‐Phylostratigraphic Evidence of Cellular and Tissue‐Level Phylogenetic Dissociation

Aging Cell, Volume 25, Issue 1, January 2026.
Aging represents an atavistic over‐representation of differential expression in the most ancient genes and under‐representation in the evolutionary youngest genes for two multi‐tissue aging databases, and tissues covering skin, ovarian, immune, senescent and mesenchymal‐senescent cells. However, some tissues like brain and mesenchymal stem cells do not
Léo Pio‐Lopez, Michael Levin
wiley   +1 more source

Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseases. [PDF]

Nat Commun
Ye M, Rotival M, Amigorena S, Zueva E.
europepmc   +1 more source