Results 41 to 50 of about 5,110,179 (281)

Single-Cell Integration of Mouse Models of Autism Reveals Conserved Transcriptomic Signatures of Excitatory-Inhibitory Imbalance and Glial Dysfunction. [PDF]

Glia
Integrated scRNA‐seq from 11 ASD models reveals convergent E/I imbalance and glial dysfunction. Conserved astrocyte and oligodendrocyte dysregulation transcend model‐specific variability. Validated by human datasets. ABSTRACT The etiological heterogeneity of autism spectrum disorder (ASD) complicates identifying core molecular mechanisms.
Nani JV, Duque VJ, Muotri AR, Mecawi AS.
europepmc   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Slash-Weighted Lindley Distribution: Properties, Inference, and Applications

Mathematics, 2023
The slash-weighted Lindley model is introduced due to the need to obtain a model with more kurtosis than the weighted Lindley distribution. Several expressions for the pdf of this model are given.
Jaime S. Castillo, Inmaculada Barranco-Chamorro, Osvaldo Venegas, Héctor W. Gómez   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Approximation process of a positive linear operator of hypergeometric type

Demonstratio Mathematica
In this article, we construct a new sequence of positive linear operators Hn:B[0,1]→C[0,1]{H}_{n}:B{[}0,1]\to C{[}0,1] using the hypergeometric distribution of probability theory and the rational values of f at the equally spaced control points k∕nk/n
Karsli Harun
doaj   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Inequalities involving hypergeometric and related functions

Journal of Inequalities and Applications, 2018
An inequality is being proved which is connected to cost-effective numerical density estimation of the hyper-gamma probability distribution. The left-hand side of the inequality is a combination of two in the third parameter distinct versions of the ...
Siegfried H. Lehnigk
doaj   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Pareto confluent hypergeometric distribution [PDF]

, 2013
In this note, is introduced a five-parameter distribution, so-called the Pareto confluent hypergeometric distribution. This new distribution generated from the logit of a confluent hypergeometric random variable includes some important distributions as ...
dos Santos Filho, Jaime, Rodrigues, Jailson Araujo, Chaves, Lucas Monteiro   +2 more
core  

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source