Results 51 to 60 of about 5,110,179 (281)

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Moments of Student’s t-distribution: a unified approach

Modern Stochastics: Theory and Applications
In this paper, new closed form formulae for moments of the (generalized) Student’s t-distribution are derived in the one dimensional case as well as in higher dimensions through a unified probability framework.
Justin Lars Kirkby, Dang H. Nguyen, Duy Nguyen   +2 more
doaj   +1 more source

Hypergeometric-Probabilities.html

, 2020
To illustrate the hypergeometric distribution, this page calculates the probability of drawing objetcts without replacement.This is the English version. Français 10.5281/zenodo.3981340.
Liebmann, Thomas
core   +1 more source

Bernstein-type bounds for beta distribution

Modern Stochastics: Theory and Applications, 2023
This work obtains sharp closed-form exponential concentration inequalities of Bernstein type for the ubiquitous beta distribution, improving upon sub-Gaussian and sub-gamma bounds previously studied in this context.
Maciej Skorski
doaj   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

A Continuous Analog of Correspondence Analysis with an Application to the Dirichlet Distribution [PDF]

The Egyptian Statistical Journal, 1993
In this article we intend to combine the well developed factorial analysis of continuous correspondence theory with Dirichlet distribution. It is pointed out that the hypergeometric function is capable of characterizing the factors playing the major role
A. Yehia
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

A Sub-Gaussian Berry-Esseen Theorem For the Hypergeometric Distribution [PDF]

, 2004
In this paper, we derive a necessary and sufficient condition on the parameters of the Hypergeometric distribution for weak convergence to a Normal limit. We establish a Berry-Esseen theorem for the Hypergeometric distribution solely under this necessary
Maiti, Tapabrata, Lahiri, Soumendra, Chatterjee, Arindam   +2 more
core  

Contractions of 2D 2nd Order Quantum Superintegrable Systems and the Askey Scheme for Hypergeometric Orthogonal Polynomials [PDF]

, 2013
We show explicitly that all 2nd order superintegrable systems in 2 dimensions are limiting cases of a single system: the generic 3-parameter potential on the 2-sphere, S9 in our listing.
Willard Miller Jr., Kalnins, Ernie G., Miller, W., Jr., Miller Jr., W., Sarah Post, Post, Sarah, Post, S., Ernest G. Kalnins, Kalnins, E.G.   +8 more
core   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source