Results 71 to 80 of about 5,110,179 (281)

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

Complete corrected formula for generating functions of the hypergeometric distribution [PDF]

The hypergeometric distribution is a popular distribution, whose properties have been extensively investigated. Generating functions of this distribution, such as the probability-generating function, the moment-generating function, and the characteristic
Yamamoto, Ken
core   +1 more source

Mating function for specific distribution patterns; is the hypergeometric function, - modified Bessel functions of order m.

, 2014
Mating function for specific distribution patterns; is the hypergeometric function, - modified Bessel functions of order m.
Charles H. King (78462), David Gurarie (119764)   +1 more
core   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

Circular Polya distributions of order k

International Journal of Mathematics and Mathematical Sciences, 2003
Two circular Polya distributions of order k are derived by means of generalized urn models and by compounding, respectively, the type I and type II circular binomial distributions of order k of Makri and Philippou (1994) with the beta distribution. It is
Gregory A. Tripsiannis, Andreas N. Philippou   +1 more
doaj   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Uses of the Hypergeometric Distribution for Determining Survival or Complete Representation of Subpopulations in Sequential Sampling [PDF]

, 2017
This thesis will explore the hypergeometric probability distribution by looking at many different aspects of the distribution. These include, and are not limited to: history and origin, derivation and elementary applications, properties, relationships to
Busbee, Brooke
core   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Bivariate Pareto–Feller Distribution Based on Appell Hypergeometric Function

Axioms
The Pareto–Feller distribution has been widely used across various disciplines to model “heavy-tailed” phenomena, where extreme events such as high incomes or large losses are of interest.
Christian Caamaño-Carrillo, Moreno Bevilacqua, Michael Zamudio-Monserratt, Javier E. Contreras-Reyes   +3 more
doaj   +1 more source

Multivariate Generalization of the Confluent Hypergeometric Function Kind 1 Distribution

International Journal of Mathematics and Mathematical Sciences, 2008
The confluent hypergeometric function kind 1 distribution with the probability density function (pdf) proportional to x_−1F11(α;β;−x),  x>0 occurs as the distribution of the ratio of independent gamma and beta variables.
Daya K. Nagar, Fabio Humberto Sepúlveda-Murillo   +1 more
doaj   +1 more source