Results 121 to 130 of about 97,549 (210)

Unraveling the major role of vascular (R2') contributions to R2* signal relaxation at ultra‐high‐field MRI: A comprehensive analysis with quantitative gradient recalled echo in mouse brain

open access: yesMagnetic Resonance in Medicine, Volume 94, Issue 2, Page 761-770, August 2025.
Abstract Purpose Ultra‐high‐field (UHF) R2* relaxometry is often used for in vivo analysis of biological tissue microstructure without accounting for vascular contributions to R2* signal, that is, the BOLD signal component, and magnetic field inhomogeneities.
Joanna Im   +7 more
wiley   +1 more source

Deciphering Important Metabolic Pathways through Reaction Pair Prediction with a Siamese Transformer Network

open access: yesChemistry–Methods, Volume 5, Issue 6, June 2025.
A deep learning‐based method Siamese transformer reaction pair (STRP) prediction is presented for identifying important pathways in untargeted LC‐MS/MS metabolomics. STRP accurately predicts metabolic reaction pairs from known metabolites and tandem mass spectra of unannotated metabolic features, which enhance the utility of untargeted metabolomics ...
Han Bao   +7 more
wiley   +1 more source

FunFEA: an R package for fungal functional enrichment analysis. [PDF]

open access: yesBMC Bioinformatics
Charest J   +3 more
europepmc   +1 more source

The Potential Role of Egg‐Derived Xeno‐miRs in Chemotherapy Response: An In Silico Approach

open access: yesFood Science &Nutrition, Volume 13, Issue 6, June 2025.
Dietary microRNAs (Xeno‐miRs), especially those homologous to human miRNAs found in animal‐based foods, may influence chemotherapy responses across cancer types. This study highlights the underexplored potential of human homolog egg‐derived Xeno‐miRs as biomarkers and therapeutic targets.
Berkcan Doğan
wiley   +1 more source

Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
We aimed to evaluate caudal IVD specimens from adult and older mice to study M0, M1, and M2 macrophage polarization and their aging‐related secretory phenotypes. Additionally, we aimed to assess macrophage polarization in aged disks, along with the differential expression of genes related to aging, and the hub genes involved in aging.
Wei Wang   +7 more
wiley   +1 more source

Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks. [PDF]

open access: yesFront Pharmacol
Díaz-Santiago E   +7 more
europepmc   +1 more source

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu   +6 more
wiley   +1 more source

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