Results 101 to 110 of about 104,423 (265)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Development of parallel computing algorithms for special mathematical functions in fractional calculus: Implementation with GPU and CUDA

Results in Engineering
This work presents the development of parallel computing algorithms for special mathematical function used in fractional calculus. A systematic and step-by-step procedure is proposed for parallelization of computation of Gamma function, 1-, 2-, 3-, and 4-
Chaitanya S. Jage, Vishwesh A. Vyawahare, Mukesh D. Patil   +2 more
doaj   +1 more source

Some exact Bradlow vortex solutions

Journal of High Energy Physics, 2017
We consider the Bradlow equation for vortices which was recently found by Manton and find a two-parameter class of analytic solutions in closed form on nontrivial geometries with non-constant curvature.
Sven Bjarke Gudnason, Muneto Nitta
doaj   +1 more source

DIHEDRAL GAUSS HYPERGEOMETRIC FUNCTIONS

Kyushu Journal of Mathematics, 2011
Gauss hypergeometric functions with a dihedral monodromy group can be expressed as elementary functions, since their hypergeometric equations can be transformed to Fuchsian equations with cyclic monodromy groups by a quadratic change of the argument variable.
openaire   +3 more sources

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Starlike Hypergeometric Functions [PDF]

Proceedings of the American Mathematical Society, 1961
Merkes, E. P., Scott, W. T.
openaire   +2 more sources

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

On the branched continued fraction expansions of the complete group of ratios of the generalized hypergeometric function $_4F_3$

Researches in Mathematics
The paper considers the classical problem of the rational approximation of analytic functions of complex variable, in particulary, to issues that arise when constructing branched continued fraction expansions for generalized hypergeometric functions ...
Y. Lutsiv, T. Antonova, R. Dmytryshyn, M. Dmytryshyn   +3 more
doaj   +1 more source

On a new class of integrals involving generalized Mittag-Leffler function [PDF]

Surveys in Mathematics and its Applications, 2016
In this paper, we aim at establishing two generalized integral formulae involving generalized Mittag-Leffler function which are expressed in terms of the generalized hypergeometric function and generalized (Wright) hypergeometric function.
Naresh Menaria, Sunil Dutt Purohit, Rakesh K. Parmar   +2 more
doaj