Results 91 to 100 of about 5,194,501 (290)

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci   +10 more
wiley   +1 more source

On the adelic Gaussian hypergeometric function [PDF]

open access: yes
We define the adelic hypergeometric function of special Gaussian type by means of a tower of hypergeometric curves. This function takes values in an adelic completed group ring and interpolates all the hypergeometric functions of the same type over all ...
Asakura, Masanori, Otsubo, Noriyuki
core   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

open access: yesCytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith   +9 more
wiley   +1 more source

Human pressure, habitat heterogeneity and species traits jointly determine the level of dark diversity in coastal fish communities

open access: yesEcography, EarlyView.
Understanding how anthropogenic pressures and environmental gradients shape coastal fish communities is a central question in biogeography and marine conservation. Yet, the set of species expected to occur at a site given ecological conditions but being absent – the so‐called dark diversity – has received far less attention than observed species, even ...
Loïc Sanchez   +23 more
wiley   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

open access: yesExploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma   +13 more
wiley   +1 more source

The Lauricella hypergeometric function

open access: yes
The problem of analytic continuation is considered for the Lauricella function F(N) D , a generalized hypergeometric functions of N complex variables.
Bezrodnykh S.I.
core   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat   +14 more
wiley   +1 more source

Inequalities for some basic hypergeometric functions

open access: yesПроблемы анализа, 2019
We establish conditions for the discrete versions of logarithmic concavity and convexity of the higher order regularized basic hypergeometric functions with respect to the simultaneous shift of all its parameters.
Kalmykov S. I., Karp D. B.
doaj   +1 more source

Decoding sequence recognition code of nucleic acid‐binding proteins of human‐infecting DNA viruses

open access: yesiMeta, EarlyView.
Human‐infecting DNA viruses remain major health threats, yet the DNA‐recognition mechanisms of their nucleic acid‐binding proteins (NBPs) are poorly understood. Here, we systematically profiled 103 viral NBPs from human‐infecting DNA viruses, with three NBPs from non‐human‐infecting DNA viruses as controls, using high‐throughput screening.
Meifang Tang   +10 more
wiley   +1 more source

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