Results 81 to 90 of about 5,545,862 (284)
Advanced Science, EarlyView.A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon +12 more
wiley +1 more source
Advanced Science, EarlyView.The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng +6 more
wiley +1 more source
Single-Cell Integration of Mouse Models of Autism Reveals Conserved Transcriptomic Signatures of Excitatory-Inhibitory Imbalance and Glial Dysfunction. [PDF]
GliaIntegrated scRNA‐seq from 11 ASD models reveals convergent E/I imbalance and glial dysfunction. Conserved astrocyte and oligodendrocyte dysregulation transcend model‐specific variability. Validated by human datasets. ABSTRACT The etiological heterogeneity of autism spectrum disorder (ASD) complicates identifying core molecular mechanisms.
Nani JV, Duque VJ, Muotri AR, Mecawi AS.
europepmc +2 more sources
A non-hypergeometric E-function
, 2021 We answer in the negative Siegel's question whether all E-functions are polynomial expressions in hypergeometric E-functions. Namely, we show that if an irreducible differential operator of order three annihilates an E-function in the hypergeometric ...
Jossen, Peter +3 more
core +1 more source
Advanced Science, EarlyView.Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu +9 more
wiley +1 more source
On the adelic Gaussian hypergeometric function [PDF]
We define the adelic hypergeometric function of special Gaussian type by means of a tower of hypergeometric curves. This function takes values in an adelic completed group ring and interpolates all the hypergeometric functions of the same type over all ...
Asakura, Masanori, Otsubo, Noriyuki
core +1 more source
Advanced Science, EarlyView.Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin +6 more
wiley +1 more source
A τ-Deformation of the Basic Horn Function H3 in q-Calculus
Journal of Function SpacesMotivated by the growing literature on basic (or q-) Horn-type series in quantum calculus and by τ-extensions of hypergeometric functions, we introduce a generalized basic τ-confluent Horn hypergeometric function H3.
Maryam G. Alshehri +3 more
doaj +1 more source
Starlike and Convex Properties for Hypergeometric Functions
International Journal of Mathematics and Mathematical Sciences, 2008 The purpose of the present paper is to give some characterizations for a (Gaussian) hypergeometric function to be in various subclasses of starlike and convex functions. We also consider an integral operator related to the hypergeometric function.
Oh Sang Kwon, Nak Eun Cho
doaj +1 more source
Fast calculation of scattering patterns using hypergeometric function algorithms. [PDF]
Sci Rep, 2023 Wagener M, Förster S.
europepmc +1 more source