Results 161 to 170 of about 5,194,501 (290)

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun   +25 more
wiley   +1 more source

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

open access: yesAlzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan   +10 more
wiley   +1 more source

Hippocampal snRNA‐seq in Collaborative Cross reveals molecular signatures of cognitive resilience independent of chronological aging

open access: yesAlzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Genetic factors contribute to variability in age‐related cognitive decline, yet the molecular mechanisms underlying cognitive resilience remain poorly understood. METHODS We performed single‐nucleus RNA sequencing on hippocampal tissue from 107 genetically diverse Collaborative Cross mice across three ages (6, 12, and 18 months ...
Yu Chen   +4 more
wiley   +1 more source

Simplified Linear Dose‐Response Models for Low‐Dose QMRAs

open access: yesAWWA Water Science, Volume 8, Issue 5, September/October 2026.
ABSTRACT This study analyzes widely used dose‐response (DR) models from potable reuse quantitative microbial risk assessments (QMRAs) to identify the low‐dose ranges where the log10‐transformed probability of infection and pathogen dose exhibit a linear relationship.
Katherine Crank   +2 more
wiley   +1 more source

Identification of lncRNAs in Breast Cancer Through Bioinformatics Analysis: Implications for Pathogenesis and Prognostic Significance

open access: yesCancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Objective Breast cancer (BC) is a disease with a subtle onset, often diagnosed late, and has a high mortality rate. This study aimed to identify long non‐coding RNAs (lncRNAs) linked to BC as prognostic markers using bioinformatics and initial experiments, explore their regulatory pathways, and assess their expression and prognostic ...
Yuhan Zheng   +5 more
wiley   +1 more source

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