Results 171 to 180 of about 5,194,501 (290)

hypeR-GEM: connecting metabolite signatures to enzyme-coding genes via genome-scale metabolic models. [PDF]

Bioinformatics
Huang Z, Perls T, Sebastiani P, Segrè D, Monti S.   +4 more
europepmc   +1 more source

USP18 Serves as a Key Mediator of cGAS‐STING for Cardiac Aging in Diabetes

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Diabetes accelerates cardiac aging, but the molecular mechanisms that link metabolic stress to myocardial senescence remain insufficiently defined. This study investigated factors driving diabetes‐associated cardiac aging with a focus on the role of USP18.
Xunxi Deng, Zhiyi Yin, Shi Tai, Hejun Jiang, Yuying Zhou, Yongjun Wang, Liyao Fu   +6 more
wiley   +1 more source

The COP9 signalosome subunit CSN1 regulates glioblastoma stem cell growth. [PDF]

PLoS One
Assaf S, Heemskerk K, Hao X, Luchman HA, Weiss S.   +4 more
europepmc   +1 more source

Arginase 2 deficiency mitigates sepsis‐associated acute kidney injury by alleviating lipid accumulation

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Spatiotemporal multi‐omics atlas reveals regional metabolic and proteomic specificity during sepsis‐to‐S‐AKI progression. 2. Arginine metabolism is central to S‐AKI pathogenesis, with declining arginine levels correlating with worsening renal function. 3. ARG2 upregulation in renal tubules and macrophages drives tubular lipid accumulation and kidney
Yu Xin, Yanqi Liu, Ning Zhang, Pengfei Huang, Qianqian Zhang, Yinghao Luo, Xinran Wang, Xiuhua Zhang, Tao Wu, Fengye Liu, Yu Xiao, Lifeng Shen, Weiting Zhang, Xibo Wang, Xianglin Meng, Yuping Bai, Xuan Wang, Nan Zhang, Qianghong Xu, Hongxue Meng, Xubin Zheng, Lixin Cheng, Kaijiang Yu, Changsong Wang   +23 more
wiley   +1 more source

On quivers, spectral networks and black holes. [PDF]

Lett Math Phys
Arnaudo P, Grassi A, Hao Q.
europepmc   +1 more source

Integrative analysis of single‐cell multi‐omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Integrative single‐cell multi‐omics analysis reveals molecular heterogeneity among piriform cortex principal neurons and identifies Reln+ superficial‐layer neurons as a selectively vulnerable population in Alzheimer's disease. Cross‐region comparison with entorhinal cortex layer II neurons reveals a shared Gpc5‐high/Sort1‐low vulnerability‐associated ...
Jiayue Meng, Miaomiao Zhang, Yujie Chen, Mengyao Han, Nianhao Cheng, Ruifang Cao, Qinwen He, Yaya Zhao, Liyun Yuan, Guoqing Zhang   +9 more
wiley   +1 more source

Single-nuclei RNA sequencing reveals obesity-associated rewiring of estrogen signaling in endometrioid adenocarcinoma. [PDF]

iScience
Long JL, Agrusa S, Pukhrambam S, Ganesh S, Gregory M, Qazi A, Faris M, Gottschlich A, Alvero A, Fehl C, Morris RT, Wallbillich JJ, Gibson HM, Gurdziel K, Dyson G, Campbell MJ, Boerner JL, Wilson MR.   +17 more
europepmc   +1 more source

Metabolite Signatures in Postpartum Prediabetes and Diabetes Among Indian Women With Prior Gestational Diabetes Mellitus: Insights From CHIP‐F Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
Metabolite Signatures in Postpartum Prediabetes and Diabetes Among Indian Women With Prior Gestational Diabetes Mellitus: Insights From CHIP‐F Study. ABSTRACT Aims Gestational diabetes mellitus (GDM) increases the risk of postpartum dysglycaemia. This study investigates candidate metabolites and perturbed metabolic pathways associated with postpartum ...
Sahil Kapoor, Ambika Singh, Neelam Mahlawat, J. Manivannan, Arpita Singh, Shinjini Bhatnagar, Nikhil Tandon, Yashdeep Gupta, Pallavi Kshetrapal   +8 more
wiley   +1 more source

Alternative Polyadenylation in the Brain is Modulated by Chronic Ethanol Exposure in a Sex- and Cell Type-Specific Manner. [PDF]

Mol Neurobiol
Grozdanov PN, Ferguson LB, Kisby BR, MacDonald CC, Messing RO, Ponomarev I.   +5 more
europepmc   +1 more source

Climatic niche divergence and high‐elevation adaptation promoted rapid diversification of Pimoa spiders in Pan‐Himalaya

Ecography, Volume 2026, Issue 9, September 2026.
The Pan‐Himalayan region harbors exceptional biodiversity, yet the origins and underlying mechanisms driving this remarkable diversity remain poorly understood, especially among species‐rich invertebrates. Pimoa spiders exhibit an intercontinental disjunct distribution across three major mountain regions: the Rockies, the Alps, and the Pan‐Himalaya ...
Xiaoqing Zhang, Zhe Zhao, Bingyue Zhu, Tongyao Jiang, Lili Shao, Stefano Mammola, Jiangni Li, Hao Xu, Bing Li, Shuqiang Li   +9 more
wiley   +1 more source