Results 231 to 240 of about 107,962 (311)

Identification of Glioma Phenotypic Subtypes From Multimodal MRI Data Using Hierarchical Multi‐Kernel Learning

Cancer Medicine, Volume 15, Issue 2, February 2026.
Our study identified glioma phenotypic subtypes based on T1CE and T2FLAIR radiomic features, along with associated pathway activities, providing real‐time insights into tumor dynamics to guide preoperative clinical decision‐making and improve patient management.
Junyu Yan, Min Hao, Tong Wang, Qi Yang, Congcong Jia, Wenju Niu, Yan Tan, Hui Zhang, Hongyan Cao, Guoqiang Yang   +9 more
wiley   +1 more source

Synergistic intragenic epigenetic deregulation by IDH2 and SRSF2 mutations causes mis-splicing of key transcriptional regulators. [PDF]

Sci Adv
Telonis AG, Stanley RF, Adelman ER, Yoshimi A, Adele AA, Cruz A, Wiseman DH, Abdel-Wahab O, Figueroa ME.   +8 more
europepmc   +1 more source

Single‐cell analysis reveals cytotoxic and memory CD8+ T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. Haplo+cord HSCT yields superior survival compared with single cord HSCT in patients with R/R leukaemia. 2. Single‐cell RNA‐seq revealed a functionally critical CD8⁺ T cell population, with cytotoxic and memory phenotypes, which expands after haplo+cord HSCT and tracks with prolonged survival. 3. Multi‐omics profiling at single‐cell resolution showed
Hua Li, Zheyang Zhang, Ming Zhu, Xiaofan Li, Jinxian Dai, Ping Chen, Fei Chen, Xianling Chen, Yiding Yang, Xiaohong Yuan, Ronghan Tang, Zhijuan Zhu, Hongli Lin, Ting Lin, Mengsha Tong, Tao Chen, Yuanzhong Chen, Jialiang Huang, Nainong Li   +18 more
wiley   +1 more source

Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity. [PDF]

Nat Metab
Ott R, Zapardiel-Gonzalo J, Kreitmaier P, Casteels K, Hommel A, Kordonouri O, Elding Larsson H, Szypowska A, Vatish M, Zeggini E, Knopff A, Winkler C, Ziegler AG, Bonifacio E, Hummel S.   +14 more
europepmc   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Exact ODE Framework for Classical and Quantum Corrections for the Lennard-Jones Second Virial Coefficient. [PDF]

Entropy (Basel)
Zhao Z, González-Calderón A, Perera-Burgos JA, Estrada A, Hernández-Anguiano H, Martínez-Lázaro C, Li Y.   +6 more
europepmc   +1 more source

Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment

Human Brain Mapping, Volume 47, Issue 2, February 1, 2026.
Morphological alterations related to depressive symptoms in mild cognitive impairment were primarily involved in emotion and affective processing, showing strong correspondence with serotonergic, dopaminergic, and GABAergic systems and enrichment of genes associated with synaptic function and excitatory neurons.
Hu Xu, Yang Li, Chensi Li, Fenglin Xu, Yun Liu, Kehan Yan, Shiyi Chen, Wenxiu Song, Yifeng Luo, Yuefeng Li   +9 more
wiley   +1 more source

Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer. [PDF]

Sci Adv
Hidmi O, Shatleh D, Flayshman SO, Monin J, Aqeilan RI.   +4 more
europepmc   +1 more source

Ciprofloxacin Treatment in Juvenile Mice Involves Neuronal Activation and Mimics Physical Features of Human Disease

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Tendinopathy is a complex, painful condition that affects up to 5% of the general population in their lifetime. Antibiotic treatment with fluoroquinolones has been associated with the onset of tendinopathy and tendon rupture. The mechanisms behind fluoroquinolone induced tendinopathy remain unclear. To probe activation of potentially causative
Nicole A. Chittim, Amro A. Hussien, Nicolo Dubacher, Gabor Matyas, Jess G. Snedeker   +4 more
wiley   +1 more source

Generation of 12 <i>major-terms</i> for interpretating human cellular processes. [PDF]

Comput Struct Biotechnol J
Liu Y, Liu R, Hu J, Wang Y, Zhang J.
europepmc   +1 more source