Results 121 to 130 of about 2,863,909 (272)

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

Epilepsia Open, EarlyView.
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher, Mathias Woidy, Franziska Plein, Tatjana Bierhals, Leonie von Elsner, Theresia Herget, Maja Hempel, Fanny Kortüm, Lev Grinstein, Julia V. Cramer, Jessika Johannsen, Jonas Denecke   +11 more
wiley   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

A Cross‐Species Hormone Knowledge Base With Multi‐Dimensional Data Integration and Intelligent Query Assistance

iMetaMed, EarlyView.
AHormoneDB is a no‐code platform that combines DOID‐standardized hormone–disease associations, regulatory prediction, and retrieval‐augmented generation‐based querying. In acromegaly, it nominated PTPN1 as a previously underappreciated candidate, demonstrating its capacity to accelerate mechanistic discovery.
Xingxing Huang, Yulong Bai, Jinfei Zhang, Lihong Zhang, Yongqiang Xing, Zhihui Zhang, Yuanping Lu   +6 more
wiley   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Parametric transformations between the Heun and gauss hypergeometric functions

, 2013
The hypergeometric and Heun functions are classical special functions. Transformation formulas between them are commonly induced by pull-back transformations of their differential equations, with respect to some coverings P1 → P1.
Vidunas, R., Filipuk, G.
core  

Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection

iMeta, EarlyView.
This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu, Xiuying Tao, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +5 more
wiley   +1 more source

From Finding a Spanning Subgraph H $H$ to an H $H$‐Factor

Journal of Graph Theory, EarlyView.
ABSTRACT A typical Dirac‐type problem in extremal graph theory is to determine the minimum degree threshold for a graph G $G$ to have a spanning subgraph H $H$, for example, the Dirac theorem. A natural follow‐up problem is to seek an H $H$‐factor, which is a spanning set of vertex‐disjoint copies of H $H$.
Allan Lo
wiley   +1 more source

NET‐Associated Inflammatory Markers in Head and Neck Squamous Cell Carcinoma: Bioinformatic Prioritization and Exploratory Serum Assessment in Patients Undergoing Radiotherapy

Molecular Carcinogenesis, EarlyView.
ABSTRACT Neutrophil extracellular traps (NETs) and inflammatory mediators have been implicated in head and neck squamous cell carcinoma, but their relationship with systemic inflammatory status during radiotherapy remains incompletely understood. This exploratory integrative study combined a literature‐guided network‐based bioinformatic prioritization ...
Eloa Mangabeira Santos, Daniela Fernanda de Freitas, David Fernando Colón, Rangel Leal Silva, Alfredo Maurício Batista de Paula, Lucyana Conceição Farias, Bruno Rodrigues Gonçalves, Andréia Luiza Oliveira Costa, Sérgio Henrique Sousa Santos, Fernando Queiroz Cunha, Donald Fernandes, André Luiz Sena Guimarães   +11 more
wiley   +1 more source

An Explicit Closed Form for a Half-Integer ₃F₂(1) Family with Negative Integral Parameter Differences, via Odd Harmonic Sums

Axioms
We study the half-integer family F(n,p)=F23−2n+12,1,2p−12;2n+52,2p+12;1. Although this family belongs to the Karlsson–Minton class of F23(1) series with negative integral parameter differences, the most directly relevant symmetric formula of Shpot and ...
Abdelhamid Zaidi
doaj   +1 more source

Recursion Formulas for Srivastava Hypergeometric Functions

, 2015
Recently, Opps, Saad and Srivastava have given the recursion formulas of Appell's function F-2 by the contiguous relation of the Gauss hypergeometric series F-2(1).
Şahin, Recep
core   +1 more source